CXXC5 - CXXC finger protein 5 Gene

Also Known as CF5; WID; RINF; HSPC195

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51523

About CXXC5

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,647,299-139,683,882 (from NCBI)

This gene has 16 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 19.6), kidney (RPKM 19.4) and 24 other tissues.

Summary

The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

CXXC5 Products (14)

mRNA Protein Name
NM_001317199.2 NP_001304128.1 CXXC-type zinc finger protein 5
NM_001317200.2 NP_001304129.1 CXXC-type zinc finger protein 5
NM_001317201.2 NP_001304130.1 CXXC-type zinc finger protein 5
NM_001317202.2 NP_001304131.1 CXXC-type zinc finger protein 5
NM_001317203.2 NP_001304132.1 CXXC-type zinc finger protein 5
NM_001317204.2 NP_001304133.1 CXXC-type zinc finger protein 5
NM_001317205.2 NP_001304134.1 CXXC-type zinc finger protein 5
NM_001317206.2 NP_001304135.1 CXXC-type zinc finger protein 5
NM_001317207.2 NP_001304136.1 CXXC-type zinc finger protein 5
NM_001317208.2 NP_001304137.1 CXXC-type zinc finger protein 5
NM_001317209.2 NP_001304138.1 CXXC-type zinc finger protein 5
NM_001317210.2 NP_001304139.1 CXXC-type zinc finger protein 5
NM_001317211.2 NP_001304140.1 CXXC-type zinc finger protein 5
NM_016463.9 NP_057547.5 CXXC-type zinc finger protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
23303788 GOA
enables methyl-CpG binding IDA
IDA: Inferred from direct assay
29276034 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23303788 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
29276034 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23303788 GOA
involved in regulation of generation of precursor metabolites and energy IDA
IDA: Inferred from direct assay
23303788 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXXC5 Protein Structure

zf-CXXC

zf-CXXC: CXXC zinc finger domain (257 - 296)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
Protein Preferred Names Protein Names

CXXC-type zinc finger protein 5

  • CXXC finger 5 protein

Related Diseases

Diseases Alias
Astroblastoma, Mn1-Altered

  • Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration
Arthrogryposis, Distal, Type 4

  • Distal Arthrogryposis Type 4

  • DA4

  • Daiid

  • Arthrogryposis-Severe Scoliosis Syndrome

  • Distal Arthrogryposis Type Iid

  • Arthrogryposis With Severe Scoliosis

  • Arthrogryposis, Distal, Type Iid
Astroblastoma

  • Cerebral Astroblastoma
Cardiomyopathy, Familial Hypertrophic, 17

  • Hypertrophic Cardiomyopathy 17

  • CMH17

  • Cardiomyopathy, Hypertrophic, 17

  • Cardiomyopathy Familial Hypertrophic 17

  • Cardiomyopathy, Familial Hypertrophic 17

  • Cardiomyopathy, Hypertrophic, Familial, Type 17
Spondyloepiphyseal Dysplasia, Kimberley Type

  • SEDK

  • Spondyloepiphyseal Dysplasia Kimberley Type

  • Spondyloepiphyseal Dysplasia Type Kimberley

  • Dysplasia, Spondyloepiphyseal, Kimberley Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131447 KY19382 98.0% Unkown
HY-124156A KY-02327 acetate Inhibitor 99.24% Unkown
HY-P11112 PTD-DBM 96.12% Unkown
HY-131448 A3334 99.64% Unkown
HY-178227 KY19334 Inhibitor / Unkown
HY-124156 KY-02327 Inhibitor / Unkown
HY-RS03415 CXXC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18171 Cxxc5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24645 Cxxc5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CXXC5 VGNC VGNC:71594
Canis familiaris CXXC5 VGNC VGNC:39754
Bos taurus CXXC5 VGNC VGNC:27860
Felis catus CXXC5 VGNC VGNC:61305
Rattus norvegicus CXXC5 RGD RGD:1359466
Mus musculus CXXC5 MGD MGI:1914643
Others CXXC5 NCBI