Tpo - thyroid peroxidase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54314

Summary

Predicted to enable iodide peroxidase activity. Involved in cellular response to nitric oxide and response to lipid. Located in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism; glomerulonephritis; and thyroid dyshormonogenesis 2A. Orthologous to human TPO (thyroid peroxidase). [provided by Alliance of Genome Resources, Apr 2022]

Tpo Products (1)

mRNA Protein Name
NM_019353.2 NP_062226.2 thyroid peroxidase precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to nitric oxide IEP
IEP: Inferred from expression pattern
17714035 RGD
involved in response to lipid IEP
IEP: Inferred from expression pattern
12748414 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15917231 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thyroid peroxidase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13463 Avatrombopag Agonist 99.83% Yes
HY-19883 Lusutrombopag Agonist 98.05% Unkown
HY-W017113 2-Mercaptobenzothiazole 99.85% Yes
HY-13463A Avatrombopag maleate 99.99% Yes
HY-13463B Avatrombopag hydrochloride Agonist 97.05% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145581 Mitiperstat Inhibitor 99.12% Phase 3

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148748 Butyzamide Activator 99.83% Unkown
HY-W017894 TPO-L 99.77% Unkown
HY-112486 TA-316 99.50% Unkown
HY-112486G TA-316 (GMP) Agonist / Unkown
HY-100380 TPO agonist 1 Agonist 98.0% Unkown
HY-148748G Butyzamide (GMP) Activator / Unkown
HY-139915 MPO-IN-1 Inhibitor 98.07% Unkown
HY-15306S Eltrombopag-13C4 97.89% Unkown
HY-19883S Lusutrombopag-d13 Agonist 98.64% Unkown
HY-13463BS Avatrombopag-d8 hydrochloride Agonist / Unkown
HY-145581B (rac)-Mitiperstat Inhibitor 98.25% Unkown
HY-145581S Mitiperstat-d3 Inhibitor / Unkown
HY-147691 MPO-IN-5 Inhibitor / Unkown
HY-153239 Eltrombopag methyl ester Agonist / Unkown
HY-RS14498 THPO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14941 TPO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16596 Tpo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17819 Thpo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23030 Tpo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990685 Romiplostim Agonist ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpo NCBI NCBI:7173