Cldn6 - claudin 6 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54419

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is essential for blastocyst formation in preimplantation mouse embryos, and is invloved in and is crucial for the formation and maintenance of the epidermal permeability barrier. This gene is adjacent to another family member Cldn9 on chromosome 17. [provided by RefSeq, Aug 2010]

Cldn6 Products (2)

mRNA Protein Name
NM_001414014.1 NP_001400943.1 claudin-6 precursor
NM_018777.5 NP_061247.1 claudin-6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10601346 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-cell junction organization IDA
IDA: Inferred from direct assay
17130295 MGI
Cellular Component GO Annotation Evidence References Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
9892664 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
9892664 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12060405 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-6

  • skullin

  • tight junction molecule claudin 6

Recombinant Cldn6 Proteins

Cat. No. Product Name Accession Purity
HY-P700692 Claudin-6/CLDN6 Protein-VLP, Mouse (HEK293) Q9Z262 (M1-V219) ≥ 95%, as determined by HPLC.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991143 Ixotatug Ligand 99% Unkown
HY-P992220 Anti-Claudin 6 Antibody (IM-302) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn6 NCBI NCBI:9074