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CLDN6 - claudin 6 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9074

About CLDN6

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,014,712-3,018,183 (from NCBI)

This gene has 3 transcripts (splice variants), 76 orthologues and 22 paralogues. Low expression observed in reference dataset.

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the Claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

CLDN6 Products (1)

mRNA	Protein	Name
NM_021195.5	NP_067018.2	claudin-6 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20375010	GOA
enables virus receptor activity	IMP IMP: Inferred from mutant phenotype	20375010	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20375010	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN6 Protein Structure

PMP22_Claudin

0
100
200
220 a.a.

Protein Preferred Names	Protein Names
claudin-6	skullin

CLDN6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLDN6	P56747	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	CLDN6	P56747	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
Intra	CLDN6	P56747	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	CLDN6	P56747	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	CLDN6	P56747	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
Intra	CLDN6	P56747	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	CLDN6	P56747	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	CLDN6	P56747	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	CLDN6	P56747	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	CLDN6	P56747	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	CLDN6	P56747	MAPK8	Homo sapiens	P45983	Anti Bait CoIP	36935496

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLDN6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77899	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, solution)	P56747 (M1-V220)	≥ 95%, as determined by HPLC.
HY-P77900	Claudin-6/CLDN6 Protein-VLP, Human (Biotinylated, HEK293)	P56747 (M1-V220)	≥ 95%, as determined by HPLC.
HY-P700406	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, His)	P56747 (M1-V220)	Purity analysis by SDS-PAGE is not available for VLP proteins.

Related Diseases

Diseases	Alias
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Lymphoplasmacyte-Rich Meningioma	Lymphoplasmocyte-Rich Meningioma Meningioma
Large Cell Medulloblastoma
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991143	Ixotatug	Ligand	99%	Unkown
HY-P992220	Anti-Claudin 6 Antibody (IM-302)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLDN6	VGNC	VGNC:80560
Macaca mulatta	CLDN6	VGNC	VGNC:71251
Rattus norvegicus	CLDN6	RGD	RGD:1308837
Bos taurus	CLDN6	VGNC	VGNC:27418
Canis familiaris	CLDN6	VGNC	VGNC:39322
Mus musculus	CLDN6	MGD	MGI:1859284
Others	CLDN6	NCBI