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DCHS2 - dachsous cadherin-related 2 Gene

Also Known as CDHJ; CDH27; CDHR7; PCDHJ; PCDH23

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54798

About DCHS2

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:154,231,742-154,491,799 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 70 orthologues and 33 paralogues. Broad expression in stomach (RPKM 1.1), testis (RPKM 0.9) and 16 other tissues.

Summary

This gene encodes a large protein that contains many Cadherin domains and likely functions in cell adhesion. Genome-wide association studies suggest that this gene may be important in Alzheimer's disease, compressive strength index, and appendicular lean mass. [provided by RefSeq, May 2017]

DCHS2 Products (3)

mRNA	Protein	Name
NM_001142552.2	NP_001136024.1	protocadherin-23 isoform 2
NM_001358235.2	NP_001345164.1	protocadherin-23 isoform 3
NM_001412223.1	NP_001399152.1	protocadherin-23 isoform 4

DCHS2 Protein Structure

Cadherin

0
500
1000
1500
2000
2500
2916 a.a.

Protein Preferred Names	Protein Names
protocadherin-23	cadherin J

Related Diseases

Diseases	Alias
Van Maldergem Syndrome	Van Maldergem Wetzburger Verloes Syndrome Cerebro-Facio-Articular Syndrome Cerebro-Facio-Articular Syndrome Of Van Maldergem Cerebrofacioarticular Syndrome Cerebro Facio Articular Syndrome Van Maldergem-Wetzburger-Verloes Syndrome
Adult Pineal Parenchymal Tumor	Adult Pineal Parenchymal Neoplasm
Adult Pineoblastoma
Luminal Breast Carcinoma B	Luminal B Breast Carcinoma
Lung Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Lung Pulmonary Adenoid Cystic Carcinoma
Hennekam Syndrome	Hennekam Lymphangiectasia Lymphedema Syndrome Hennekam Lymphangiectasia-Lymphedema Syndrome Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome Lymphangiectasies And Lymphedema Hennekam Type Generalized Lymphatic Dysplasia Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03576	DCHS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DCHS2	RGD	RGD:1563329
Felis catus	DCHS2	VGNC	VGNC:78479
Mus musculus	DCHS2	MGD	MGI:2685263
Macaca mulatta	DCHS2	VGNC	VGNC:100217