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UBE2R2 - ubiquitin conjugating enzyme E2 R2 Gene

Also Known as UBC3B; CDC34B; E2-CDC34B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54926

About UBE2R2

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,815,168-33,920,399 (from NCBI)

This gene has 1 transcript (splice variant), 137 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 25.6), endometrium (RPKM 16.9) and 25 other tissues.

Summary

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]

UBE2R2 Products (1)

mRNA	Protein	Name
NM_017811.4	NP_060281.2	ubiquitin-conjugating enzyme E2 R2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	20061386	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20061386	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2R2 Protein Structure

UQ_con

0
100
200
238 a.a.

Protein Preferred Names	Protein Names
ubiquitin-conjugating enzyme E2 R2	E2 ubiquitin-conjugating enzyme R2

UBE2R2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBE2R2	Q712K3	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	UBE2R2	Q712K3	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	UBE2R2	Q712K3	MEOX1	Homo sapiens	P50221	Validated Y2H	25416956
Intra	UBE2R2	Q712K3	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	UBE2R2	Q712K3	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	UBE2R2	Q712K3	MEOX1	Homo sapiens	P50221	Y2H Array	25416956
Intra	UBE2R2	Q712K3	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	UBE2R2	Q712K3	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	UBE2R2	Q712K3	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	UBE2R2	Q712K3	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2R2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71407	UBE2R2 Protein, Human (His)	Q712K3 (M1-S238)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Clear Cell Adenofibroma	Cystadenofibroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15360	UBE2R2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19826	Ube2r2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26322	Ube2r2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBE2R2	MGD	MGI:1914865
Bos taurus	UBE2R2	VGNC	VGNC:36594
Canis familiaris	UBE2R2	VGNC	VGNC:48064
Rattus norvegicus	UBE2R2	RGD	RGD:1594826
Others	UBE2R2	NCBI