FAIM - Fas apoptotic inhibitory molecule Gene

Also Known as FAIM1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55179

About FAIM

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,608,771-138,633,376 (from NCBI)

This gene has 9 transcripts (splice variants) and 276 orthologues. Ubiquitous expression in fat (RPKM 4.9), thyroid (RPKM 4.0) and 25 other tissues.

Summary

The protein encoded by this gene protects against death receptor-triggered Apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

FAIM Products (4)

mRNA Protein Name
NM_001033030.2 NP_001028202.1 fas apoptotic inhibitory molecule 1 isoform a
NM_001033031.2 NP_001028203.1 fas apoptotic inhibitory molecule 1 isoform b
NM_001033032.2 NP_001028204.1 fas apoptotic inhibitory molecule 1 isoform c
NM_018147.4 NP_060617.1 fas apoptotic inhibitory molecule 1 isoform c

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAIM Protein Structure

FAIM1

FAIM1: Fas apoptotic inhibitory molecule (FAIM1) (1 - 176)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

fas apoptotic inhibitory molecule 1

FAIM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FAIM Q9NVQ4 WDR47 Homo sapiens O94967
Anti Tag CoIP
33961781
Intra
FAIM Q9NVQ4 SPRY2 Homo sapiens O43597
Validated Y2H
25416956
Intra
FAIM Q9NVQ4 SPRY2 Homo sapiens O43597
Y2H Array
25416956
Intra
FAIM Q9NVQ4 SPRY2 Homo sapiens O43597
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Osteogenesis Imperfecta, Type X

  • Osteogenesis Imperfecta Type 10

  • OI10

  • Osteogenesis Imperfecta Type X

  • Oi, Type X

  • Osteogenesis Imperfecta 10

  • Oi Type X

  • Oi-X
Milker'S Nodule

  • Poxviridae Infections

  • Milker Nodule

  • Milkers' Node

  • Paravaccinia

  • Pseudocowpox

  • Milker'S Nodes
Kwashiorkor

  • Kwashiokor

  • Nutritional Edema With Dyspigmentation Of Skin And Hair

  • Nutritional Oedema With Dyspigmentation Of Skin And/Or Hair
Contagious Pustular Dermatitis

  • Ecthyma, Contagious

  • Orf

  • Ecthyma Contagiosum

  • Scabby Mouth

  • Sheep Pox

  • Thistle Disease

  • Contagious Pustular Dermatosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04675 FAIM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04674 FAIM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19896 Faim Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20922 Faim2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26397 Faim Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27439 Faim2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FAIM VGNC VGNC:72297
Mus musculus FAIM MGD MGI:1344387
Rattus norvegicus FAIM RGD RGD:620572
Felis catus FAIM VGNC VGNC:102694
Bos taurus FAIM VGNC VGNC:28709
Canis familiaris FAIM VGNC VGNC:40570
Others FAIM NCBI