Sfn - stratifin Gene

Also Known as Er; Mme1; Ywhas; 14-3-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 55948

Summary

Enables phosphoprotein binding activity and protein kinase binding activity. Involved in several processes, including establishment of skin barrier; positive regulation of protein export from nucleus; and regulation of epidermal cell division. Acts upstream of or within keratinocyte differentiation; negative regulation of keratinocyte proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin). [provided by Alliance of Genome Resources, Apr 2022]

Sfn Products (1)

mRNA Protein Name
NM_018754.2 NP_061224.2 14-3-3 protein sigma

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
17938205 MGI
enables protein binding IDA
IDA: Inferred from direct assay
18606808 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16710422 MGI
enables protein kinase binding IDA
IDA: Inferred from direct assay
10767298 MGI
Biological Process GO Annotation Evidence References Source
involved in cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
18606808 MGI
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
24075906 MGI
acts upstream of or within keratinization IMP
IMP: Inferred from mutant phenotype
6174530 MGI
acts upstream of or within keratinocyte development IGI
IGI: Inferred from genetic interaction
24075906 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
16239341 MGI
acts upstream of keratinocyte proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18606808 MGI
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
16710422 MGI
involved in positive regulation of epidermal cell differentiation IMP
IMP: Inferred from mutant phenotype
24075906 MGI
involved in positive regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
17938205 MGI
involved in protein export from nucleus IDA
IDA: Inferred from direct assay
18606808 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
10767298 MGI
acts upstream of or within regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10767298 MGI
involved in regulation of epidermal cell division IMP
IMP: Inferred from mutant phenotype
24075906 MGI
acts upstream of or within skin development IGI
IGI: Inferred from genetic interaction
17041603 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
16239341 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
17041603 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16710422 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16710422 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

14-3-3 protein sigma

  • 14-3-3 sigma protein

  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide

Recombinant Sfn Proteins

Cat. No. Product Name Accession Purity
HY-P74438 14-3-3 sigma Protein, Mouse O70456 (M1-S248) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132242 DL-Sulforaphane N-acetyl-L-cysteine 99.90% Unkown
HY-RS12769 SFN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11864 REXO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16629 Sfn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20094 Rexo2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23064 Sfn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W588248 DL-Sulforaphane glutathione / Unkown
HY-W710753 D,L-Sulforaphane glutathione-d5 / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991589 SFN68 Inhibitor 99.87% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sfn NCBI NCBI:2810