Bace2 - beta-site APP-cleaving enzyme 2 Gene

Also Known as ARP1; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; 1110059C24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56175

About Bace2

Chromosome 16: 97,157,942-97,244,136 forward strand.GRCm39:CM001009.3

This gene has 4 transcripts (splice variants), 215 orthologues, 8 paralogues and is associated with 10 phenotypes. Biased expression in stomach adult (RPKM 52.5), colon adult (RPKM 18.7) and 8 other tissues.

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein undergoes proteolytic processing to generate an active endopeptidase enzyme. This transmembrane protease catalyzes the proteolysis of amyloid precursor protein to produce amyloid beta peptide. Mice lacking the encoded product exhibit increased pancreatic beta cell mass and improved glucose tolerance due to increased Insulin secretion. [provided by RefSeq, Jul 2016]

Bace2 Products (1)

mRNA Protein Name
NM_019517.5 NP_062390.3 beta-secretase 2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IGI
IGI: Inferred from genetic interaction
31838721 MGI
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
31838721 MGI
Biological Process GO Annotation Evidence References Source
involved in melanosome organization IMP
IMP: Inferred from mutant phenotype
23754390 MGI
involved in signaling receptor ligand precursor processing IGI
IGI: Inferred from genetic interaction
31838721 MGI
involved in signaling receptor ligand precursor processing IMP
IMP: Inferred from mutant phenotype
31838721 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
21907142 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bace2 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (84 - 445)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

beta-secretase 2

  • aspartyl protease 1

  • beta-site amyloid precursor protein cleaving enzyme 2

  • memapsin-1

  • membrane-associated aspartic protease 1

  • theta-secretase

Recombinant Bace2 Proteins

Cat. No. Product Name Accession Purity
HY-P75588 BACE2 Protein, Mouse (HEK293, His) Q9JL18 (A20-P462) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136742 BACE2-IN-1 Inhibitor 99.4% Unkown
HY-124322 NB-360 Inhibitor 99.08% Unkown
HY-12938 AMG-8718 Inhibitor / Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown
HY-147758 BACE1/2-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bace2 NCBI NCBI:25825