Foxo1 - forkhead box O1 Gene

Mus musculus

Also known as Afxh; FKHR; Fkhr1; Foxo1a

Gene ID: 56458 | Gene type: protein coding

About Foxo1

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to Insulin stimulus; cellular response to nitric oxide; and negative regulation of fat cell differentiation. Acts upstream of or within several processes, including Insulin Receptor signaling pathway; neuronal stem cell population maintenance; and positive regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Apr 2022]

Foxo1 Products(1)

mRNA	Protein	Name
NM_019739.3	NP_062713.2	forkhead box protein O1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12488434	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17090532	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12488434	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12219087	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	19896444	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17090532	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	29320745	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22514318	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17050673	MGI
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	22417654	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11353388	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	17090532	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	21196578	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	14978268	MGI
acts upstream of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19896444	MGI
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	17681146	MGI
involved in cellular response to nitric oxide	IDA IDA: Inferred from direct assay	21196578	MGI
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	22417654	MGI
acts upstream of or within gene expression	IGI IGI: Inferred from genetic interaction	29867121	MGI
acts upstream of or within glucose homeostasis	IDA IDA: Inferred from direct assay	21317886	MGI
acts upstream of or within insulin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	29867121	MGI
acts upstream of or within insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12488434	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19896444	MGI
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	17681146	MGI
involved in negative regulation of insulin secretion	IDA IDA: Inferred from direct assay	12219087	MGI
acts upstream of or within neuronal stem cell population maintenance	IGI IGI: Inferred from genetic interaction	19896444	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	29320745	MGI
acts upstream of or within positive regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	12783775	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17550780	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12783775	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12488434	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12488434	MGI
acts upstream of or within regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	18497885	MGI
acts upstream of or within regulation of neural precursor cell proliferation	IGI IGI: Inferred from genetic interaction	19896444	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IGI IGI: Inferred from genetic interaction	19896444	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17090532	MGI
involved in response to fatty acid	IDA IDA: Inferred from direct assay	32103177	MGI
acts upstream of or within response to insulin	IGI IGI: Inferred from genetic interaction	29867121	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12488434	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	27457971	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12488434	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein O1

forkhead box O1a	forkhead box protein O1A
forkhead in rhabdomyosarcoma	forkhead protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2440	Gypenoside A	Activator	99.79%	Unkown
HY-137038	N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride	Inhibitor	/	Unkown
HY-179498	ROCK2-IN-13	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxo1	NCBI	NCBI:2308

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