Foxo1 - forkhead box O1 Gene

Also Known as Afxh; FKHR; Fkhr1; Foxo1a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56458

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to Insulin stimulus; cellular response to nitric oxide; and negative regulation of fat cell differentiation. Acts upstream of or within several processes, including Insulin Receptor signaling pathway; neuronal stem cell population maintenance; and positive regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Apr 2022]

Foxo1 Products (1)

mRNA Protein Name
NM_019739.3 NP_062713.2 forkhead box protein O1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12488434 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17090532 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12488434 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12219087 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
19896444 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17090532 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
29320745 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22514318 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17050673 MGI
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
22417654 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11353388 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
17090532 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
21196578 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
14978268 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19896444 MGI
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
17681146 MGI
involved in cellular response to nitric oxide IDA
IDA: Inferred from direct assay
21196578 MGI
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
22417654 MGI
acts upstream of or within gene expression IGI
IGI: Inferred from genetic interaction
29867121 MGI
acts upstream of or within glucose homeostasis IDA
IDA: Inferred from direct assay
21317886 MGI
acts upstream of or within insulin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
29867121 MGI
acts upstream of or within insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12488434 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19896444 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
17681146 MGI
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
12219087 MGI
acts upstream of or within neuronal stem cell population maintenance IGI
IGI: Inferred from genetic interaction
19896444 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
29320745 MGI
acts upstream of or within positive regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
12783775 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17550780 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12783775 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12488434 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12488434 MGI
acts upstream of or within regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
18497885 MGI
acts upstream of or within regulation of neural precursor cell proliferation IGI
IGI: Inferred from genetic interaction
19896444 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IGI
IGI: Inferred from genetic interaction
19896444 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17090532 MGI
involved in response to fatty acid IDA
IDA: Inferred from direct assay
32103177 MGI
acts upstream of or within response to insulin IGI
IGI: Inferred from genetic interaction
29867121 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12488434 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
27457971 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12488434 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein O1

  • forkhead box O1a

  • forkhead box protein O1A

  • forkhead in rhabdomyosarcoma

  • forkhead protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2440 Gypenoside A Activator 99.79% Unkown
HY-137038 N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride Inhibitor / Unkown
HY-13024A Rebastinib tosylate Inhibitor / Unkown
HY-179498 ROCK2-IN-13 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxo1 NCBI NCBI:2308