Foxo3 - forkhead box O3 Gene

Also Known as Fkhr2; FKHRL1; Foxo3a; 1110048B16Rik; 2010203A17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56484

Summary

Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial transcription; positive regulation of muscle atrophy; and positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; female gonad development; and neuronal stem cell population maintenance. Located in cytosol; mitochondrial outer membrane; and nucleus. Part of protein-containing complex. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to human FOXO3 (forkhead box O3). [provided by Alliance of Genome Resources, Apr 2022]

Foxo3 Products (2)

mRNA Protein Name
NM_001376967.1 NP_001363896.1 forkhead box protein O3
NM_019740.3 NP_062714.1 forkhead box protein O3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14966295 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19933931 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14966295 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
19896444 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17521387 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
17521387 MGI
enables mitochondrial transcription factor activity IMP
IMP: Inferred from mutant phenotype
23283301 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17521387 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11353388 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19933931 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response, signal transduction by p53 class mediator IDA
IDA: Inferred from direct assay
15383658 MGI
acts upstream of or within antral ovarian follicle growth IMP
IMP: Inferred from mutant phenotype
14978268 MGI
acts upstream of or within brain morphogenesis IGI
IGI: Inferred from genetic interaction
24483844 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19896444 MGI
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
17521387 MGI
acts upstream of or within cellular response to oxidative stress IGI
IGI: Inferred from genetic interaction
24483844 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: Inferred from genetic interaction
12431371 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
12855809 MGI
acts upstream of or within initiation of primordial ovarian follicle growth IMP
IMP: Inferred from mutant phenotype
12855809 MGI
involved in mitochondrial transcription IMP
IMP: Inferred from mutant phenotype
23283301 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19896444 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21621563 MGI
acts upstream of or within neuronal stem cell population maintenance IGI
IGI: Inferred from genetic interaction
19896444 MGI
acts upstream of or within oocyte maturation IMP
IMP: Inferred from mutant phenotype
12855809 MGI
acts upstream of or within ovulation from ovarian follicle IMP
IMP: Inferred from mutant phenotype
12855809 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12048180 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18054315 MGI
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
18054315 MGI
involved in positive regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
19933931 MGI
involved in positive regulation of muscle atrophy IDA
IDA: Inferred from direct assay
18054315 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12930811 MGI
acts upstream of or within regulation of neural precursor cell proliferation IGI
IGI: Inferred from genetic interaction
19896444 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IGI
IGI: Inferred from genetic interaction
19896444 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17521387 MGI
involved in response to fatty acid IDA
IDA: Inferred from direct assay
32103177 MGI
involved in response to starvation IDA
IDA: Inferred from direct assay
18054315 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12857750 MGI
located in cytosol IDA
IDA: Inferred from direct assay
18054315 MGI
located in membrane IDA
IDA: Inferred from direct assay
15383658 MGI
colocalizes with mitochondrial matrix IDA
IDA: Inferred from direct assay
29445193 MGI
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
29445193 MGI
colocalizes with mitochondrion IDA
IDA: Inferred from direct assay
23283301 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12857750 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
23283301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein O3

  • forkhead box O3a

  • forkhead protein FKHR2

Foxo3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Foxo3 Q9WVH4 SETD7 Homo sapiens Q8WTS6
Methyltransferase Ass
22402663
Cross
Foxo3 Q9WVH4 SETD7 Homo sapiens Q8WTS6
Anti Tag CoIP
22402663
Intra
Foxo3 Q9WVH4 Fcor Mus musculus P0DJI6
Anti Tag CoIP
22510882
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-154919 DC-Y13-27 Activator 99.52% Unkown
HY-176902 NSC126188 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxo3 NCBI NCBI:2309