PSAP - prosaposin Gene

Also Known as GLBA; SAP1; SAP2; PSAPD; PARK24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5660

About PSAP

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:71,816,298-71,851,251 (from NCBI)

This gene has 4 transcripts (splice variants), 228 orthologues, 2 paralogues and is associated with 12 phenotypes. Ubiquitous expression in spleen (RPKM 523.6), gall bladder (RPKM 491.5) and 25 other tissues.

Summary

This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

PSAP Products (3)

mRNA	Protein	Name
NM_001042465.3	NP_001035930.1	prosaposin isoform b preproprotein
NM_001042466.3	NP_001035931.1	prosaposin isoform c preproprotein
NM_002778.4	NP_002769.1	prosaposin isoform a preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ganglioside GM1 binding	IDA IDA: Inferred from direct assay	1454804	GOA
enables ganglioside GM2 binding	IDA IDA: Inferred from direct assay	1454804	GOA
enables ganglioside GM3 binding	IDA IDA: Inferred from direct assay	1454804	GOA
enables ganglioside GP1c binding	IDA IDA: Inferred from direct assay	1454804	GOA
enables ganglioside GT1b binding	IDA IDA: Inferred from direct assay	1454804	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18462685	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	14674747	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	24872419	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18462685	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	23555801	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ganglioside GM1 transport to membrane	IDA IDA: Inferred from direct assay	1454804	GOA
involved in lysosomal transport	IDA IDA: Inferred from direct assay	26370502	GOA
involved in lysosomal transport	IMP IMP: Inferred from mutant phenotype	28541286	GOA
involved in positive regulation of beta-galactosidase activity	IDA IDA: Inferred from direct assay	1454804	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	1454804	GOA
located in late endosome	IDA IDA: Inferred from direct assay	26370502	GOA
located in lysosome	IDA IDA: Inferred from direct assay	22431521	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSAP Protein Structure

SapA

SapB_1

SapB_2

SapB_1

SapB_2

SapB_1

SapB_2

SapB_1

SapB_2

SapA

0
100
200
300
400
500
524 a.a.

Protein Preferred Names	Protein Names
prosaposin	proactivator polypeptide

PSAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSAP	P07602	PEX5	Homo sapiens	P50542-3	Y2H Prey Pooling	32296183
Intra	PSAP	P07602	PEX5	Homo sapiens	P50542-3	Validated Y2H	32296183
Intra	PSAP	P07602	PEX5	Homo sapiens	P50542-3	Y2H Array	32296183
Intra	PSAP	P07602	ZBED1	Homo sapiens	O96006	Y2H Array	16713569
Intra	PSAP	P07602	ZBED1	Homo sapiens	O96006	Y2H Array	32296183
Intra	PSAP	P07602	ZBED1	Homo sapiens	O96006	Y2H Prey Pooling	32296183
Intra	PSAP	P07602	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183
Intra	PSAP	P07602	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	PSAP	P07602	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	PSAP	P07602	GRN	Homo sapiens	P28799	IF	26370502
Intra	PSAP	P07602	LYN	Homo sapiens	P07948	Y2H Array	32814053
Intra	PSAP	P07602	LYN	Homo sapiens	P07948	Validated Y2H	32814053
Intra	PSAP	P07602	LYN	Homo sapiens	P07948	Y2H Pooling	32814053
Intra	PSAP	P07602	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	PSAP	P07602	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	PSAP	P07602	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PSAP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76553	PSAP/Prosaposin Protein, Human (HEK293, His)	NP_002769.1 (G17-N524)	≥ 95%, as determined by reducing SDS-PAGE.

PSAP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82938	PSAP Antibody (YA2683)	WB, IHC-P	Human
HY-P83993	PSAP Antibody (YA3690)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat
HY-P83993A	PSAP Antibody (YA3690)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Gaucher Disease, Atypical, Due To Saposin C Deficiency	Gaucher Disease, Atypical Atypical Gaucher Disease Due To Saposin C Deficiency Atypical Gaucher Disease GDSAPC Saposin C Deficiency Atypical Gaucher'S Disease Due To Saposin C Deficiency AGD
Combined Saposin Deficiency	Encephalopathy Due To Prosaposin Deficiency Combined Sap Deficiency PSAPD Prosaposin Deficiency Combined Prosaposin Deficiency CSAPD Saposin Deficiency, Combined
Metachromatic Leukodystrophy Due To Saposin B Deficiency	Metachromatic Leukodystrophy Due To Cerebroside Sulfatase Activator Deficiency Saposin B Deficiency Metachromatic Leukodystrophy Due To Sap-B Deficiency MLDSAPB Metachromatic Leukodystrophy Due To Saposin-B Deficiency MLD-SAPB Activator Deficiency Leukodystrophy, Metachromatic, Due To Saposin-B Deficiency
Krabbe Disease, Atypical, Due To Saposin A Deficiency	Saposin A Deficiency Krabbe Disease, Atypical KRBSAPA Krabbe Disease Atypical Due To Saposin A Deficiency AKRD
Parkinson Disease 24, Autosomal Dominant	Parkinson Disease 24, Autosomal Dominant, Susceptibility To PARK24
Metachromatic Leukodystrophy	Arylsulfatase A Deficiency MLD Arsa Deficiency Sulfatide Lipidosis Metachromatic Leukoencephalopathy Cerebral Sclerosis, Diffuse, Metachromatic Form Cerebroside Sulfatase Deficiency Leukodystrophy, Metachromatic Pseudoarylsulfatase A Deficiency Leukodystrophy Metachromatic Sulfatidosis Metachromatic Leukodystrophy, Late Infantile Metachromatic Leukodystrophy Variant Deficiency Of Cerebroside-Sulfatase Scholz Cerebral Sclerosis Sulfatide Lipoidosis Cerebral Sclerosis Diffuse Metachromatic Form Arylsulfatase A Deficiency Disease Cerebroside Sulphatase Deficiency Disease Greenfield Disease Metachromatic Leukodystrophy, Adult Metachromatic Leukodystrophy, Juvenile Leukodystrophy Metachromatic Adult Leukodystrophy Metachromatic Juvenile Leukodystrophy Metachromatic Late Infantile Metachromatic Leukodystrophy, Adult Type Metachromatic Leukodystrophy, Juvenile Type Metachromatic Leukodystrophy, Infant Greenfield'S Disease
Infantile Krabbe Disease	Krabbe Disease, Classic Form Krabbe Disease, Early-Onset Infantile Globoid Cell Leukodystrophy
Metachromatic Leukodystrophy, Adult Form	Arylsulfatase A Deficiency, Adult Form Mld, Adult Form
Metachromatic Leukodystrophy, Late Infantile Form	Arylsulfatase A Deficiency, Late Infantile Form Mld, Late Infantile Form
Metachromatic Leukodystrophy, Juvenile Form	Arylsulfatase A Deficiency, Juvenile Form Mld, Juvenile Form
Hereditary Late-Onset Parkinson Disease	Autosomal Dominant Late-Onset Parkinson Disease Lopd Hereditary Late Onset Parkinson Disease
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Sphingolipidosis	Sphingolipidoses
Krabbe Disease	Globoid Cell Leukodystrophy Galactosylceramide Beta-Galactosidase Deficiency Galc Deficiency Galactocerebrosidase Deficiency GLD Globoid Cell Leukoencephalopathy Diffuse Globoid Body Sclerosis Gcl Leukodystrophy, Globoid Cell Krabbe'S Leukodystrophy Krabbe Leukodystrophy KRB Beta Galactocerebrosidase Deficiency Krabbe'S Disease Galactosylceramidase Deficiency Disease Galactosylceramide Lipidosis Galactosylcerebrosidase Deficiency Galactosylsphingosine Lipidosis Psychosine Lipidosis Galactosylceramidase Deficiency Infantile Globoid Cell Leukodystrophy Krabbe Brain Sclerosis
Leukodystrophy	Leukodystrophies
Gm2 Gangliosidosis	Gangliosidosis Gm2 Gangliosidoses, Gm2
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Gangliosidosis	Gangliosidoses
Tay-Sachs Disease	Hexosaminidase A Deficiency TSD Hexa Deficiency Gm2 Gangliosidosis, Type 1 Hexosaminidase Alpha-Subunit Deficiency Gm2-Gangliosidosis, Several Forms Gm2-Gangliosidosis, B, B1, Ab Variant B Variant Gm2 Gangliosidosis Sphingolipidosis, Tay-Sachs Gm2-Gangliosidosis, Type I B Variant Gm2-Gangliosidosis Hex A Pseudodeficiency Hexa Disorders Beta-Hexosaminidase A Deficiency Gm2 Gangliosidosis, Type I Gangliosidosis Gm2 , Type 1 Gm2 Gangliosidosis, B, B1 Variant Gm2-Gangliosidosis 1 GM2G1 Gm2-Gangliosidosis B Variant Tay-Sachs Disease Pseudo-Ab Variant Tay-Sachs Disease Variant B1 Gangliosidoses, Gm2
Fabry Disease	Alpha-Galactosidase A Deficiency Anderson-Fabry Disease Angiokeratoma Corporis Diffusum Ceramide Trihexosidase Deficiency Fabry Disease, Cardiac Variant Fabry'S Disease Hereditary Dystopic Lipidosis Gla Deficiency FD Alpha Galactosidase Deficiency Deficiency Of Melibiase Angiokeratoma, Diffuse Angiokeratoma Diffuse Diffuse Angiokeratoma
Gaucher Disease, Type Iii	Gaucher Disease, Subacute Neuronopathic Type Gd Iii Gaucher Disease, Chronic Neuronopathic Type Gaucher Disease, Juvenile And Adult, Cerebral Gaucher Disease Type 3 GD3 Gaucher'S Disease Type Iii Gaucher Disease Type Iii Gd 3 Cerebral Juvenile And Adult Form Of Gaucher Disease Chronic Neuronopathic Gaucher Disease Gaucher Disease 3 Cerebral, Juvenile And Adult, Gaucher Disease Gaucher Disease Chronic Neuronopathic Type Gaucher Disease Type Ii Subacute Neuronopathic Gaucher Disease Type 3 Gaucher Disease Gaucher Disease, Type 3 Gaucher Disease, Type 2
Glycoproteinosis	Sialidosis Mucolipidosis Type I Mucolipidoses Cherry Red Spot Myoclonus Syndrome Mucolipidosis I Myoclonus Cherry Red Spot Syndrome Type I Mucolipidosis Lipomucopolysaccharidosis Disorders Of Glycoprotein Metabolism Glycoprotein Storage Disorder
Mucolipidosis Ii Alpha/Beta	I-Cell Disease Mucolipidosis Type Ii Mucolipidosis Ii Icd Inclusion Cell Disease Inclusion-Cell Disease I Cell Disease Mucolipidosis 2 MLII Ml Ii Ml Ii Alpha/Beta Gnpta Leroy Disease Ml 2 Ml Disorder Type 2 N-Acetylglucosamine 1phosphotransferase Deficiency Mucolipidosis Type Ii Alpha/Beta N-Acetylglucosamine 1-Phosphotransferase Deficiency Deficiency Of N-Acetylglucosamine-1-Phosphotransferase Mucolipidosis, Type Ii, Alpha/Beta Ml2 Type Ii Mucolipidosis
Niemann-Pick Disease	Sphingomyelin/Cholesterol Lipidosis Niemann-Pick Diseases Lipoid Histiocytosis Sphingomyelin Lipidosis Sphingomyelinase Deficiency Disease Lipid Histiocytosis Neuronal Cholesterol Lipidosis Neuronal Lipidosis Npd Sphingomyelinase Deficiency Niemann-Pick Disease, Type A
Gaucher Disease, Type Ii	GD2 Gd Ii Gaucher Disease, Acute Neuronopathic Type Gaucher Disease Type 2 Gaucher Disease Type Ii Gaucher'S Disease Type Ii Infantile Cerebral Gaucher Disease Acute Neuronopathic Gaucher Disease Gd 2 Gaucher Disease, Infantile Cerebral Gaucher Disease 2 Type 2 Gaucher Disease Gaucher Disease, Type 2
Gm1 Gangliosidosis	Beta-Galactosidase Deficiency Gangliosidosis Gm1 Deficiency Of Beta-Galactosidase Beta Galactosidase 1 Deficiency Beta-Galactosidosis Glb 1 Deficiency Beta-Galactosidase-1 Deficiency Beta-Galactosidase-1 Deficiency Glb1 Deficiency Landing Disease Gangliosidosis, Gm1
Bacterial Gastritis
Gaucher Disease, Type I	Glucocerebrosidase Deficiency Acid Beta-Glucosidase Deficiency Gba Deficiency GD1 Gd I Gaucher Disease, Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Type I Gaucher'S Disease Type I Gaucher Disease Gd 1 Non-Cerebral Juvenile Gaucher Disease GD Gaucher Disease 1 Adult Non-Neuronopathic Gaucher Disease Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Gaucher Disease, Type 1
Gaucher Disease, Type Iiic	Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome Gaucher-Like Disease GD3C Gaucher'S Disease Type Iiic Cardiovascular Gaucher Disease Gaucher Disease Type 3c Gaucher Disease 3c Pseudo-Gaucher Disease
Niemann-Pick Disease, Type C1	Niemann-Pick Disease, Type C NPC1 Niemann-Pick Disease, Type D Niemann-Pick Disease Type C1 Niemann-Pick Disease With Cholesterol Esterification Block Niemann-Pick Disease, Subacute Juvenile Form Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia Npc Niemann-Pick Disease, Chronic Neuronopathic Form Niemann-Pick Disease Without Sphingomyelinase Deficiency Niemann-Pick Disease Type C Niemann-Pick Disease Type D Niemann-Pick C1 Disease Niemann-Pick Disease C1 Niemann-Pick Disease Chronic Neuronopathic Form Niemann-Pick Disease Nova Scotian Type Niemann-Pick Disease Subacute Juvenile Form Niemann-Pick Disease Type Ii Niemann-Picks Disease Type C
Schindler Disease	Alpha-N-Acetylgalactosaminidase Deficiency Naga Deficiency Alpha-Galactosidase B Deficiency Alpha-Galnac Deficiency, Schindler Type Alpha-Naga Deficiency Angiokeratoma Corporis Diffusum-Glycopeptiduria Galb Deficiency Kanzaki Disease Lysosomal Glycoaminoacid Storage Disease-Angiokeratoma Corporis Diffusum Neuroaxonal Dystrophy, Schindler Type Neuronal Axonal Dystrophy, Schindler Type Schindler Disease, Type I Schindler Disease, Type Ii
Gaucher Disease, Perinatal Lethal	Gaucher Disease Perinatal Lethal Gaucher Disease, Collodion Type Gaucher'S Disease Perinatal Lethal Fetal Gaucher Disease Perinatal Lethal Gaucher Disease Gaucher Disease Collodion Type Gaucher Disease, Perinatal-Lethal Form GDPL
Lysosomal Storage Disease	Lysosomal Storage Diseases Disorder Of Lysosomal Enzyme Inborn Lysosomal Enzyme Disorder Lysosomal Storage Metabolism Disorder Lysosomal Storage Disorder
Farber Lipogranulomatosis	Farber Disease Acid Ceramidase Deficiency Ceramidase Deficiency Ac Deficiency N-Laurylsphingosine Deacylase Deficiency Farber'S Disease FRBRL Farber'S Lipogranulomatosis Acylsphingosine Deacylase Deficiency Farber-Uzman Syndrome Acy
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Galactosialidosis	Goldberg Syndrome Neuraminidase Deficiency With Beta-Galactosidase Deficiency Ppca Deficiency GSL Lysosomal Protective Protein Deficiency Cathepsin A Deficiency Neuraminidase/Beta-Galactosidase Expression Protective Protein/Cathepsin A Deficiency Ngbe Cathepsin A Deficiency Of Lysosomal Protective Protein Deficiency Of Deficiency Of Cathepsin A Neuraminidase Beta-Galactosidase Deficiency Protective Protein Cathepsin A Deficiency
Gm2-Gangliosidosis, Ab Variant	Hexosaminidase Activator Deficiency Tay-Sachs Disease, Ab Variant Gm2 Gangliosidosis, Ab Variant Gm2 Activator Deficiency Tay-Sachs Disease, Variant Ab Tay-Sachs Disease Ab Variant Ab Variant Gm2-Gangliosidosis Tay-Sachs Variant Ab Ab Variant Activator Deficiency/Gm2 Gangliosidosis Activator-Deficient Tay-Sachs Disease Gm2 Activator Deficiency Disease Gm2 Gangliosidosis, Type Ab Gm2-Gangliosidosis Ab GM2GAB Gm2-Gangliosidosis Ab Variant Gangliosidosis Gm2 Ab Variant Gm2-Gangliosidosis, Variant Ab
Sandhoff Disease	Total Hexosaminidase Deficiency Hexosaminidases A And B Deficiency Sandhoff Disease, Infantile, Juvenile, And Adult Forms Beta-Hexosaminidase-Beta-Subunit Deficiency Gm2 Gangliosidosis, Type 2 Hexosaminidase A And B Deficiency Disease Sandhoff-Jatzkewitz-Pilz Disease Gm2 Gangliosidosis, Type Ii Sandhoff Disease, Infantile Form Sandhoff Disease, Adult Form Sandhoff Disease, Juvenile Form Gm2-Gangliosidosis, Type Ii Sandhoff Jatzkewitz Disease Type Ii Gm2 Gangliosidosis Gm2 Gangliosidosis, 0 Variant Gm2 Gangliosidosis 0 Variant Hexosaminidases A And B Deficiency, Infantile Form Infantile Gm2 Gangliosidosis 0 Variant Adult Gm2 Gangliosidosis 0 Variant Hexosaminidases A And B Deficiency, Adult Form Hexosaminidases A And B Deficiency, Juvenile Form Juvenile Gm2 Gangliosidosis 0 Variant Gm2-Gangliosidosis 2 GM2G2 Hexosaminidase A And B Deficiency Sd
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Aspartylglucosaminuria	Aspartylglycosaminuria Glycosylasparaginase Deficiency Aspartylglucosaminidase Deficiency Aga Deficiency AGU Aspartylglucosamidase Deficiency Glycoasparaginase Aspartylglucosamidase Deficiency Hyperammonemia, Type Iii
Mucolipidosis
Niemann-Pick Disease, Type A	Niemann-Pick Disease Type A Sphingomyelin Lipidosis Sphingomyelinase Deficiency Niemann-Pick Disease, Intermediate, Protracted Neurovisceral Acid Sphingomyelinase Deficiency, Neurovisceral Type Asmd, Neurovisceral Type Infantile Neurovisceral Acid Sphingomyelinase Deficiency Infantile Neurovisceral Asmd Npd-A Niemann-Pick Disease A NPDA Classical Niemann-Pick Disease Niemann-Pick Disease Acute Neuronopathic Form Niemann-Pick Disease Acute Neurovisceral Form Niemann-Pick Disease Classical Infantile Form Niemann-Pick Disease Intermediate Protracted Neurovisceral Niemann-Pick Disease Neuronopathic Type Niemann-Pick Disease Type I Npa Niemann-Pick Diseases
Niemann-Pick Disease, Type B	Niemann-Pick Disease Type B Acid Sphingomyelinase Deficiency, Visceral Type Asmd, Visceral Type Niemann Pick Disease Type B Chronic Visceral Acid Sphingomyelinase Deficiency Chronic Visceral Asmd Npd-B Niemann-Pick Disease B NPDB Niemann-Pick Disease Adult Non-Neuronopathic Form Niemann-Pick Disease Intermediate With Visceral Involvement And Rapid Progression Niemann-Pick Disease Type E Niemann-Pick Disease Type F Niemann-Pick Disease Type I Niemann-Pick Disease Visceral Form Npb Sphingomyelinase Deficiency Sphingomyelin Lipidosis Niemann-Picks Disease Type B Niemann-Pick Disease, Type E Niemann-Pick Diseases Niemann-Pick Disease, Type A
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157926	Nitroso-PSAP		/	Unkown
HY-RS08754	MTCH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11269	PSAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12780	SFTPA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12781	SFTPA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17269	Psap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22651	Mtch1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23723	Psap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99358	Dezamizumab	Activator	99.79%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PSAP	VGNC	VGNC:45080
Bos taurus	PSAP	VGNC	VGNC:33431
Rattus norvegicus	PSAP	RGD	RGD:3423
Felis catus	PSAP	VGNC	VGNC:69093
Macaca mulatta	PSAP	VGNC	VGNC:76434
Mus musculus	PSAP	MGD	MGI:97783
Others	PSAP	NCBI