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BMAL2 - basic helix-loop-helix ARNT like 2 Gene

Also Known as CLIF; MOP9; PASD9; ARNTL2; bHLHe6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56938

About BMAL2

Cytogenetic location: 12p11.23 Genomic coordinates (GRCh38): 12:27,332,836-27,425,286 (from NCBI)

This gene has 9 transcripts (splice variants), 245 orthologues and 6 paralogues. Broad expression in esophagus (RPKM 6.4), appendix (RPKM 3.2) and 17 other tissues.

Summary

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

BMAL2 Products (11)

mRNA	Protein	Name
NM_001248002.3	NP_001234931.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 2
NM_001248003.3	NP_001234932.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 3
NM_001248004.3	NP_001234933.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 4
NM_001248005.3	NP_001234934.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 5
NM_001394524.1	NP_001381453.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 6
NM_001394525.1	NP_001381454.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 7
NM_001394526.1	NP_001381455.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 8
NM_001394527.1	NP_001381456.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 9
NM_001394528.1	NP_001381457.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 10
NM_001394529.1	NP_001381458.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 11
NM_020183.6	NP_064568.3	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12055078	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15147242	GOA
enables E-box binding	IDA IDA: Inferred from direct assay	12738229	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15147242	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11018023	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	10864977	GOA
acts upstream of or within circadian rhythm	IDA IDA: Inferred from direct assay	10864977	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10864977	GOA
involved in positive regulation of circadian rhythm	IDA IDA: Inferred from direct assay	12738229	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15147242	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12055078	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CLOCK-BMAL transcription complex	IPI IPI: Inferred from physical interaction	10864977	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12055078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMAL2 Protein Structure

HLH

PAS

PAS_11

0
100
200
300
400
500
600
636 a.a.

Protein Preferred Names	Protein Names
aryl hydrocarbon receptor nuclear translocator-like protein 2	CYCLE-like factor

BMAL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BMAL2	Q8WYA1	CLOCK	Homo sapiens	O15516	Anti Tag CoIP	33961781
Intra	BMAL2	Q8WYA1	CLOCK	Homo sapiens	O15516	Y2H	11018023

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hepatorenal Syndrome	Hepato-Renal Syndrome Hepatorenal Failure Hrf - [Hepatorenal Failure] Hepatorenal Degeneration Hepatic Renal Syndrome Hepatic Renal Failure Renal Hepatic Failure Urohepatic Syndrome
Hepatic Vascular Disease	Vascular Disorder Of Liver
Acute Kidney Failure	Acute Renal Failure Acute Kidney Injury Renal Failure Acute Kidney Failure, Acute Pre-Renal Acute Kidney Injury Nontraumatic Acute Kidney Injury Aki - [Acute Kidney Injury] Arf - [Acute Kidney Failure] Acute Kidney Disease Acute Kidney Impairment Acute Ischaemic Renal Failure Acute Hypoxic Kidney Failure Acute Kidney Shutdown Acute Renal Oedema Acute Renal Impairment Acute Kidney Collapse Acute Necrotising Kidney Acute Renal Suppression
Esophageal Varix	Esophageal Varices Bleeding Esophageal Varices Bleeding Oesophageal Varices Esophageal Varices In Disease Classified Elsewhere, With Bleeding Esophageal Varices With Bleeding Esophageal Varices With Bleeding In Disease Ec Esophageal Varices Without Bleeding Esophageal Varices Without Mention Of Bleeding
Delayed Sleep Phase Disorder	Delayed Sleep Phase Syndrome Delayed Sleep Phase Syndrome, Susceptibility To DSPD Delayed Sleep Phase Disorder, Susceptibility To DSPS Sleep Phase, Delayed, Disorder Sleep Phase Syndrome, Delayed, Susceptibility To
Advanced Sleep Phase Syndrome	Fasps Familial Advanced Sleep-Phase Syndrome Advanced Sleep Phase Syndrome, Familial Familial Advanced Sleep Phase Syndrome Sleep Phase Syndrome, Advanced, Familial Advanced Sleep-Phase Syndrome, Familial
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01530	BMAL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BMAL2	VGNC	VGNC:83500
Rattus norvegicus	BMAL2	RGD	RGD:620230
Mus musculus	BMAL2	MGD	MGI:2684845
Bos taurus	BMAL2	VGNC	VGNC:49075
Canis familiaris	BMAL2	VGNC	VGNC:48873
Macaca mulatta	BMAL2	VGNC	VGNC:99889
Others	BMAL2	NCBI