TRPC7 - transient receptor potential cation channel subfamily C member 7 Gene

Also Known as TRP7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57113

About TRPC7

This gene has 7 transcripts (splice variants), 226 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated Calcium Channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within calcium ion transport. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TRPC7 Products (4)

mRNA Protein Name
NM_001167576.2 NP_001161048.1 short transient receptor potential channel 7 isoform 3
NM_001167577.2 NP_001161049.1 short transient receptor potential channel 7 isoform 2
NM_001376901.1 NP_001363830.1 short transient receptor potential channel 7 isoform 4
NM_020389.3 NP_065122.1 short transient receptor potential channel 7 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21402151 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC7 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (51 - 128)

TRP_2

TRP_2: Transient receptor ion channel II (198 - 260)

Ion_trans

Ion_trans: Ion transport protein (442 - 672)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 862 a.a.
Protein Preferred Names Protein Names

short transient receptor potential channel 7

  • likley ortholog of mouse transient receptor potential cation channel, subfamily C, member 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161766 L687 Activator 99.49% Unkown
HY-162090 TRPC antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRPC7 RGD RGD:628820
Bos taurus TRPC7 VGNC VGNC:36387
Canis familiaris TRPC7 VGNC VGNC:47872
Mus musculus TRPC7 MGD MGI:1349470
Felis catus TRPC7 VGNC VGNC:66587
Macaca mulatta TRPC7 VGNC VGNC:79280
Others TRPC7 NCBI