S100A14 - S100 calcium binding protein A14 Gene

Also Known as BCMP84; S100A15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57402

About S100A14

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,614,255-153,616,325 (from NCBI)

This gene has 6 transcripts (splice variants), 355 orthologues and 21 paralogues. Biased expression in esophagus (RPKM 798.1), skin (RPKM 171.2) and 6 other tissues.

Summary

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]

S100A14 Products (1)

mRNA Protein Name
NM_020672.3 NP_065723.1 protein S100-A14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemokine receptor binding IMP
IMP: Inferred from mutant phenotype
18606705 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to bacterium IEP
IEP: Inferred from expression pattern
17625598 GOA
involved in positive regulation of granulocyte chemotaxis IDA
IDA: Inferred from direct assay
18606705 GOA
involved in positive regulation of monocyte chemotaxis IDA
IDA: Inferred from direct assay
18606705 GOA
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17625598 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
17625598 GOA
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11944983 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A14 Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (19 - 58)

  • 0
  • 104 a.a.
Protein Preferred Names Protein Names

protein S100-A14

  • S114

S100A14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
S100A14 Q9HCY8 MAGEA6 Homo sapiens P43360
Validated Y2H
25416956
Intra
S100A14 Q9HCY8 MAGEA6 Homo sapiens P43360
Y2H Array
25416956
Intra
S100A14 Q9HCY8 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
25416956
Intra
S100A14 Q9HCY8 S100A16 Homo sapiens Q96FQ6
Validated Y2H
25416956
Intra
S100A14 Q9HCY8 S100A16 Homo sapiens Q96FQ6
Y2H Prey Pooling
25416956
Intra
S100A14 Q9HCY8 S100A16 Homo sapiens Q96FQ6
Y2H Array
25416956
Intra
S100A14 Q9HCY8 S100A16 Homo sapiens Q96FQ6
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A14 Proteins

Cat. No. Product Name Accession Purity
HY-P76584 S100A14 Protein, Human (His) Q9HCY8.1 (G2-H104) ≥ 85%, as determined by reducing SDS-PAGE.

S100A14 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89536 S-100A14 Antibody (YA8880) ICC/IF, IF-Tissue, IHC-P, ELISA human

Related Diseases

Diseases Alias
Trachea Leiomyoma

  • Tracheal Neoplasms

  • Leiomyoma Of The Trachea

  • Tracheal Neoplasm

  • Tracheal Leiomyoma
Small Intestine Adenocarcinoma

  • Small Intestinal Adenocarcinoma

  • Adenocarcinoma Of Small Intestine

  • Adenocarcinoma Of The Small Bowel

  • Adenocarcinoma Of Small Bowel

  • Adenocarcinoma Of Small Instestine

  • Adenocarcinoma Of The Small Instestine

  • Small Bowel Adenocarcinoma

  • Adenocarcinoma Of The Small Intestine
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12376 S100A14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17154 S100a11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19550 S100a14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26046 S100a14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus S100A14 VGNC VGNC:34240
Mus musculus S100A14 MGD MGI:1913416
Canis familiaris S100A14 VGNC VGNC:45826
Felis catus S100A14 VGNC VGNC:64839
Rattus norvegicus S100A14 RGD RGD:1595063
Others S100A14 NCBI