Tk2 - thymidine kinase 2, mitochondrial Gene

Also Known as mt-TK

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57813

Summary

Predicted to enable deoxycytidine kinase activity and thymidine kinase activity. Acts upstream of or within deoxyribonucleotide metabolic process; mitochondrial DNA metabolic process; and mitochondrial DNA replication. Located in mitochondrion. Used to study mitochondrial DNA depletion syndrome 2. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 and mitochondrial DNA depletion syndrome 2. Orthologous to human TK2 (thymidine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tk2 Products (1)

mRNA Protein Name
NM_021028.3 NP_066356.3 thymidine kinase 2, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables deoxycytidine kinase activity IDA
IDA: Inferred from direct assay
11023833 MGI
enables thymidine kinase activity IDA
IDA: Inferred from direct assay
11023833 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within deoxyribonucleotide metabolic process IMP
IMP: Inferred from mutant phenotype
18467430 MGI
acts upstream of or within mitochondrial DNA metabolic process IMP
IMP: Inferred from mutant phenotype
18467430 MGI
acts upstream of or within mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
18434326 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrion IDA
IDA: Inferred from direct assay
11023833 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
10571069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thymidine kinase 2, mitochondrial

  • 2'-deoxyuridine kinase TK2

  • deoxycytidine kinase TK2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W008907 5'-O-Tritylthymidine Inducer 99.79% Unkown
HY-128710 2'-Fluorothymidine 99.07% Unkown
HY-W353804 2′-Deoxy-β-L-uridine 99.96% Unkown
HY-RS14556 TK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14557 TK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128710R 2'-Fluorothymidine (Standard) / Unkown
HY-RS17628 Tk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24088 Tk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tk2 NCBI NCBI:7084