Rnf8 - ring finger protein 8 Gene

Also Known as AIP37; laXp180; 3830404E21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58230

Summary

Enables histone binding activity and ubiquitin protein Ligase activity. Involved in DNA metabolic process; histone ubiquitination; and spermatogenesis, exchange of chromosomal proteins. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in central nervous system; genitourinary system; nasal cavity epithelium; and thymus primordium. Orthologous to human RNF8 (ring finger protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Rnf8 Products (1)

mRNA Protein Name
NM_021419.2 NP_067394.1 E3 ubiquitin-protein ligase RNF8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone binding IMP
IMP: Inferred from mutant phenotype
19015238 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22101936 MGI
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
19015238 MGI
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
19015238 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
21857671 MGI
involved in double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
21857671 MGI
involved in isotype switching IMP
IMP: Inferred from mutant phenotype
20080757 MGI
involved in signal transduction in response to DNA damage IMP
IMP: Inferred from mutant phenotype
19015238 MGI
involved in sperm DNA condensation IMP
IMP: Inferred from mutant phenotype
20153262 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
21857671 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
28552346 MGI
located in nucleus IDA
IDA: Inferred from direct assay
28552346 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF8

  • ActA binding protein 2

  • RING-type E3 ubiquitin transferase RNF8

  • actA-interacting protein 37

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12097 RNF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18369 Rnf8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24848 Rnf8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf8 NCBI NCBI:9025