Acan - aggrecan Gene

Also Known as Agc; Agc1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58968

Summary

Enables calcium ion binding activity. Involved in several processes, including chondroblast differentiation; response to acidic pH; and response to glucose. Located in several cellular components, including extracellular space; neuronal cell body; and perineuronal net. Used to study degenerative disc disease. Biomarker of congestive heart failure; degenerative disc disease; osteoarthritis; and status epilepticus. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kimberley type. Orthologous to human ACAN (aggrecan). [provided by Alliance of Genome Resources, Apr 2022]

Acan Products (1)

mRNA Protein Name
NM_022190.2 NP_071526.2 aggrecan core protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
15296743 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
19968598 RGD
involved in chondroblast differentiation IEP
IEP: Inferred from expression pattern
20001227 RGD
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
8641562 RGD
involved in ossification IEP
IEP: Inferred from expression pattern
20047194 RGD
involved in response to acidic pH IEP
IEP: Inferred from expression pattern
19133233 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
18670337 RGD
involved in response to gravity IEP
IEP: Inferred from expression pattern
18245988 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19968598 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18279833 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18628692 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
18364019 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
20603097 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
22306080 RGD
located in perineuronal net IDA
IDA: Inferred from direct assay
18364019 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aggrecan core protein

  • CSPCP

  • aggrecan 1

  • aggrecan, structural proteoglycan of cartilage

  • cartilage-specific proteoglycan core protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19820A NSC45586 sodium 98.0% Unkown
HY-165607S MCB-22-174 99.78% Unkown
HY-RS00132 ACAN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17876 Acan Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24345 Acan Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acan NCBI NCBI:176