RLN1 - relaxin 1 Gene

Also Known as H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6013

About RLN1

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,334,930-5,340,916 (from NCBI)

This gene has 2 transcripts (splice variants), 81 orthologues and 3 paralogues. Biased expression in prostate (RPKM 8.0) and testis (RPKM 0.2).

Summary

Relaxins are known endocrine and autocrine/paracrine Hormones, belonging to the Insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]

RLN1 Products (1)

mRNA Protein Name
NM_006911.4 NP_008842.1 prorelaxin H1 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RLN1 Protein Structure

Insulin

Insulin: Insulin/IGF/Relaxin family (32 - 185)

  • 0
  • 100
  • 185 a.a.
Protein Preferred Names Protein Names

prorelaxin H1

  • preprorelaxin H1

RLN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RLN1 P04808 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
RLN1 P04808 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
RLN1 P04808 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
RLN1 P04808 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
RLN1 P04808 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RLN1 Proteins

Cat. No. Product Name Accession Purity
HY-P77176 RLN1/Relaxin-1 Protein, Human (HEK293, His) P04808 (V23-C185) ≥ 90%, as determined by reducing SDS-PAGE.

RLN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82110 Relaxin 2 Antibody (YA1855) WB, IHC-P Human, Mouse, Rat
HY-P82110A Relaxin 2 Antibody (YA1855)(PBS only) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Spermatogenic Failure 8

  • SPGF8
Extragonadal Germ Cell Cancer

  • Extragonadal Germ Cell Tumor

  • Extragonadal Germ Cell Malignant Tumor

  • Neoplasm Of Extragonadal Germ Cell

  • Tumor Of Extragonadal Germ Cell
Chromosome 9p Deletion Syndrome

  • Monosomy 9p

  • Monosomy 9p Syndrome

  • Alfi Syndrome

  • 9p Syndrome

  • Chromosome 9p Deletion

  • 9p Deletion

  • 9p Monosomy

  • Deletion 9p

  • Partial Monosomy 9p

  • 9p Deletion Syndrome

  • 9p- Syndrome

  • Alfi'S Syndrome

  • Chromosome 9, Partial Trisomy 9p
Testicular Germ Cell Cancer

  • Germ Cell Tumor Of Testis

  • Testicular Germ Cell Tumor

  • Testicular Germ Cell Neoplasm

  • Testicular Malignant Germ Cell Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12009 RLN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21424 Rln1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27942 Rln1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RLN1 RGD RGD:3579
Mus musculus RLN1 MGD MGI:97931