RLN1 - relaxin 1 Gene

Homo sapiens

Also known as H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2

Gene ID: 6013 | Gene type: protein coding

About RLN1

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,334,930-5,340,916 (from NCBI)

This gene has 2 transcripts (splice variants), 81 orthologues and 3 paralogues. Biased expression in prostate (RPKM 8.0) and testis (RPKM 0.2).

Summary

Relaxins are known endocrine and autocrine/paracrine Hormones, belonging to the Insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]

RLN1 Products(1)

mRNA	Protein	Name
NM_006911.4	NP_008842.1	prorelaxin H1 preproprotein

RLN1 Protein Structure

Insulin

0
100
185 a.a.

Protein Preferred Names

Protein Names

prorelaxin H1

preprorelaxin H1

Recombinant RLN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77176	RLN1/Relaxin-1 Protein, Human (HEK293, His)	P04808 (V23-C185)	≥95%

Related Diseases

Diseases

Alias

Spermatogenic Failure 8

SPGF8

Extragonadal Germ Cell Cancer

Extragonadal Germ Cell Tumor	Extragonadal Germ Cell Malignant Tumor
Neoplasm Of Extragonadal Germ Cell	Tumor Of Extragonadal Germ Cell

Chromosome 9p Deletion Syndrome

Monosomy 9p	Monosomy 9p Syndrome
Alfi Syndrome	9p Syndrome
Chromosome 9p Deletion	9p Deletion
9p Monosomy	Deletion 9p
Partial Monosomy 9p	9p Deletion Syndrome
9p- Syndrome	Alfi'S Syndrome
Chromosome 9, Partial Trisomy 9p

Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis	Testicular Germ Cell Tumor
Testicular Germ Cell Neoplasm	Testicular Malignant Germ Cell Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12009	RLN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RLN1	RGD	RGD:3579
Mus musculus	RLN1	MGD	MGI:97931