Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

Also Known as Fxr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60351

About Nr1h4

Primary_assembly 7: 23,846,122-23,942,047 reverse strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 388 orthologues, 19 paralogues and is associated with 37 phenotypes. Biased expression in Liver (RPKM 265.5) and Kidney (RPKM 198.2).

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid receptor activity; and chenodeoxycholic acid binding activity. Contributes to double-stranded DNA binding activity. Involved in several processes, including lipid homeostasis; liver development; and negative regulation of biosynthetic process. Located in nucleus. Part of receptor complex. Used to study extrahepatic cholestasis; intrahepatic cholestasis; and portal hypertension. Biomarker of bile duct disease (multiple); liver disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; and premature menopause. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h4 Products (1)

mRNA Protein Name
NM_021745.1 NP_068513.1 bile acid receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11533040 RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11533040 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11533040 RGD
enables bile acid binding IDA
IDA: Inferred from direct assay
12718893 RGD
enables bile acid binding IPI
IPI: Inferred from physical interaction
12718893 RGD
enables bile acid nuclear receptor activity IDA
IDA: Inferred from direct assay
10334992 RGD
enables chenodeoxycholic acid binding IDA
IDA: Inferred from direct assay
10334992 RGD
contributes to double-stranded DNA binding IDA
IDA: Inferred from direct assay
15047603 RGD
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
10334992 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
12718893 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
11533040 RGD
Biological Process GO Annotation Evidence References Source
involved in bile acid and bile salt transport IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in bile acid metabolic process IDA
IDA: Inferred from direct assay
12754200 RGD
involved in bile acid metabolic process IMP
IMP: Inferred from mutant phenotype
27993716 RGD
involved in cellular response to bile acid IDA
IDA: Inferred from direct assay
10334992 RGD
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
29235094 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
27090119 RGD
involved in cholesterol homeostasis IDA
IDA: Inferred from direct assay
19136377 RGD
involved in cholesterol homeostasis IEP
IEP: Inferred from expression pattern
23117815 RGD
involved in digestive tract development IEP
IEP: Inferred from expression pattern
11984532 RGD
involved in leukocyte migration involved in inflammatory response IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
15980055 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15860571 RGD
involved in negative regulation of triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
29148806 RGD
involved in nuclear receptor-mediated bile acid signaling pathway IDA
IDA: Inferred from direct assay
10334992 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
27993716 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11533040 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17065154 RGD
involved in regulation of carbohydrate metabolic process IMP
IMP: Inferred from mutant phenotype
15564327 RGD
involved in regulation of lipid storage IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10334992 RGD
involved in response to cholesterol IEP
IEP: Inferred from expression pattern
25263431 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
27090119 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
15047603 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12492453 RGD
involved in response to norepinephrine IMP
IMP: Inferred from mutant phenotype
19418582 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
23117815 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
29091898 RGD
involved in triglyceride homeostasis IDA
IDA: Inferred from direct assay
19136377 RGD
involved in triglyceride homeostasis IEP
IEP: Inferred from expression pattern
23117815 RGD
Cellular Component GO Annotation Evidence References Source
part of receptor complex IDA
IDA: Inferred from direct assay
10334992 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr1h4 Protein Structure

NR_DBD_FXR

NR_DBD_FXR: cd06962 (163 - 250)

NR_LBD_Fxr

NR_LBD_Fxr: cd06936 (291 - 510)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 516 a.a.
Protein Preferred Names Protein Names

bile acid receptor

  • RXR-interacting protein 14

  • farnesoid X-activated receptor

  • farnesol receptor HRR-1

  • retinoid X receptor-interacting protein 14

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125996 NR1H4 activator 1 Agonist / Unkown
HY-RS09531 NR1H4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09532 Nr1h4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09533 Nr1h4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182395 DM175 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr1h4 NCBI NCBI:9971