Il21 - interleukin 21 Gene

Also Known as IL-21

Species: Mus musculus

Gene Type: protein coding
Gene ID: 60505

Summary

Enables cytokine receptor binding activity. Involved in cellular response to virus; lymphocyte activation involved in immune response; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of cytokine production; positive regulation of natural killer cell differentiation; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular space. Is expressed in ductus deferens; epididymis; and testis. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21). [provided by Alliance of Genome Resources, Apr 2022]

Il21 Products (2)

mRNA Protein Name
NM_001291041.1 NP_001277970.1 interleukin-21 isoform 1 precursor
NM_021782.3 NP_068554.1 interleukin-21 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytokine receptor binding IDA
IDA: Inferred from direct assay
11081504 MGI
Biological Process GO Annotation Evidence References Source
involved in T follicular helper cell differentiation IMP
IMP: Inferred from mutant phenotype
23045607 MGI
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
23045607 MGI
involved in germinal center B cell differentiation IMP
IMP: Inferred from mutant phenotype
23045607 MGI
acts upstream of interleukin-10 production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of natural killer cell cytokine production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of natural killer cell differentiation IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
14764669 MGI
involved in positive regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
23045607 MGI
acts upstream of or within positive regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of or within positive regulation of natural killer cell cytokine production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of type II interferon production IDA
IDA: Inferred from direct assay
14764669 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-21

Recombinant Il21 Proteins

Cat. No. Product Name Accession Purity
HY-P7078 IL-21 Protein, Mouse Q9ES17 (H18-S146) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70643 IL-21 Protein, Mouse (122a.a) Q9ES17 (P25-S146) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78149 IL-21 Protein, Mouse (Biotinylated, His-Avi) Q9ES17 (H18-S146) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700199AF Animal-Free IL-21 Protein, Mouse (His) Q9ES17 (H18-S146) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700294 IL-21 Protein, Mouse (His) Q9ES17 (P25-S146) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P991271 NN-8828 Inhibitor 97.89% Phase 2
HY-P991272 ATR-107 Inhibitor 99.9% Phase 1
HY-P99687 Latikafusp Inhibitor 99.40% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162490 TF-S14 Inhibitor / Unkown
HY-RS06734 IL21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06735 IL21R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06736 IL22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174621 Human IL21R mRNA / Unkown
HY-174622 Human IL21 mRNA / Unkown
HY-RS16691 Il21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22573 Il21r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23126 Il21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29091 Il21r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990218 Anti-Mouse IL-21R Antibody (4A9) 99.96% Unkown
HY-P992241 Anti-IL-21R Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il21 NCBI NCBI:59067