Rad50 - RAD50 double strand break repair protein Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64012

Summary

Enables double-stranded DNA binding activity. Involved in several processes, including cellular response to DNA damage stimulus; negative regulation of viral entry into host cell; and response to human chorionic gonadotropin. Located in several cellular components, including inclusion body; nuclear lumen; and perinuclear region of cytoplasm. Used to study liver cirrhosis and myocardial infarction. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein). [provided by Alliance of Genome Resources, Apr 2022]

Rad50 Products (1)

mRNA Protein Name
NM_022246.2 NP_071582.2 DNA repair protein RAD50

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
21956462 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12615909 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18212738 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IEP
IEP: Inferred from expression pattern
11056294 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
10908350 RGD
involved in negative regulation of viral entry into host cell IMP
IMP: Inferred from mutant phenotype
22850678 RGD
involved in response to human chorionic gonadotropin IEP
IEP: Inferred from expression pattern
23239112 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
10855503 RGD
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
10855503 RGD
located in inclusion body IDA
IDA: Inferred from direct assay
18212738 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
18212738 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18212738 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair protein RAD50

  • RAD50 homolog, double strand break repair protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19959 Mirin 99.63% Unkown
HY-117693 (E/Z)-Mirin Inhibitor 99.22% Unkown
HY-149972 Antitumor agent-96 Inducer / Unkown
HY-RS11602 RAD50 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18404 Rad50 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24885 Rad50 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rad50 NCBI NCBI:10111