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Dapk3 - death-associated protein kinase 3 Gene

Also Known as Dapkl

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64391

Summary

Enables ATP binding activity; protein C-terminus binding activity; and protein serine/threonine kinase activity. Involved in several processes, including intracellular signal transduction; neuron differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in several cellular components, including actin filament; membrane raft; and nucleus. Orthologous to human DAPK3 (death associated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Dapk3 Products (1)

mRNA	Protein	Name
NM_022546.2	NP_071991.1	death-associated protein kinase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10602480	RGD
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11884640	RGD
enables kinase activity	IDA IDA: Inferred from direct assay	10602480	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10602480	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10602480	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	10602480	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10602480	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	12445468	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10602480	RGD
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	21172653	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament	IDA IDA: Inferred from direct assay	10602480	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	21172653	RGD
located in nucleus	IDA IDA: Inferred from direct assay	10602480	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
death-associated protein kinase 3	DAP kinase 3 DAP-like kinase Death-associated like kinase MYPT1 kinase ZIP-kinase dlk

Dapk3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Dapk3	O88764	Pawr	Rattus norvegicus	Q62627	Y2H	10602480
Intra	Dapk3	O88764	Pawr	Rattus norvegicus	Q62627	Pull Down	10602480

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125404	DAPK-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dapk3	NCBI	NCBI:1613