DAPK3 - death associated protein kinase 3 Gene

Also Known as DLK; ZIP; ZIPK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1613

About DAPK3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,958,453-3,971,099 (from NCBI)

This gene has 7 transcripts (splice variants), 152 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 16.5), prostate (RPKM 15.3) and 25 other tissues.

Summary

Death-associated protein kinase 3 (DAPK3) induces morphological changes in Apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of Apoptosis. [provided by RefSeq, Jul 2008]

DAPK3 Products (2)

mRNA	Protein	Name
NM_001348.3	NP_001339.1	death-associated protein kinase 3
NM_001375658.1	NP_001362587.1	death-associated protein kinase 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10356987	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18239682	GOA
enables leucine zipper domain binding	IPI IPI: Inferred from physical interaction	10580117	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15292222	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18239682	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10356987	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	23454120	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	10580117	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	12917339	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	18995835	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10356987	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	18995835	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21487036	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21454679	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18239682	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10356987	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	23454120	GOA
involved in regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	23454120	GOA
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21487036	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAPK3 Protein Structure

Pkinase

0
100
200
300
400
454 a.a.

Protein Preferred Names	Protein Names
death-associated protein kinase 3	DAP kinase 3

DAPK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DAPK3	O43293	LUZP1	Homo sapiens	Q86V48	Pull Down	32707033
Intra	DAPK3	O43293	LUZP1	Homo sapiens	Q86V48	Anti Tag CoIP	35271311
Intra	DAPK3	O43293	PPP1R12A	Homo sapiens	O14974	Anti Tag CoIP	15292222
Intra	DAPK3	O43293	PPP1R12A	Homo sapiens	O14974	Pull Down	15292222
Intra	DAPK3	O43293	NLK	Homo sapiens	Q9UBE8	Anti Bait CoIP	21454679
Intra	DAPK3	O43293	DAPK3	Homo sapiens	O43293	X-Ray Diffraction	18239682
Intra	DAPK3	O43293	DAPK3	Homo sapiens	O43293	Solution Sedimentation	18239682
Intra	DAPK3	O43293	CEP170	Homo sapiens	Q5SW79	Pull Down	32707033
Intra	DAPK3	O43293	DAPK3	Homo sapiens	O43293	Anti Tag CoIP	21487036

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DAPK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77286	DAPK3/ZIPK Protein, Human (sf9, GST)	O43293-1 (M1-R454)	≥ 85%, as determined by reducing SDS-PAGE.

DAPK3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83574	DAP kinase 3 Antibody (YA3319)	WB	Human
HY-P83574A	DAP kinase 3 Antibody (YA3319)(PBS only)	WB	Human
HY-P83838	DAP kinase 3 Antibody (YA3535)	WB, IHC-P, FC, ELISA	Human
HY-P83838A	DAP kinase 3 Antibody (YA3535)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125404	DAPK-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DAPK3	VGNC	VGNC:61338
Bos taurus	DAPK3	VGNC	VGNC:27878
Mus musculus	DAPK3	MGD	MGI:1203520
Macaca mulatta	DAPK3	VGNC	VGNC:71734
Rattus norvegicus	DAPK3	RGD	RGD:621766
Canis familiaris	DAPK3	VGNC	VGNC:39771
Others	DAPK3	NCBI