Il12b - interleukin 12B Gene

Also Known as Il12

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64546

About Il12b

Primary_assembly 10: 28,893,008-28,902,903 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 268 orthologues and is associated with 29 phenotypes. Biased expression in Thymus (RPKM 25.2), Spleen (RPKM 18.6) and 1 other tissue.

Summary

Enables interleukin-12 alpha subunit binding activity. Involved in natural killer cell activation involved in immune response and sensory perception of pain. Located in extracellular space. Part of interleukin-12 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B). [provided by Alliance of Genome Resources, Apr 2022]

Il12b Products (1)

mRNA Protein Name
NM_022611.2 NP_072133.2 interleukin-12 subunit beta precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-12 alpha subunit binding IDA
IDA: Inferred from direct assay
16716808 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
16716808 RGD
Biological Process GO Annotation Evidence References Source
involved in natural killer cell activation involved in immune response IMP
IMP: Inferred from mutant phenotype
14960310 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10415618 RGD
part of interleukin-12 complex IDA
IDA: Inferred from direct assay
16716808 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il12b Protein Structure

Ig_3

Ig_3: pfam13927 (41 - 89)

Ig

Ig: cd00096 (45 - 49)

Ig

Ig: cd00096 (56 - 60)

Ig

Ig: cd00096 (74 - 78)

Ig

Ig: cd00096 (86 - 91)

IL12p40_C

IL12p40_C: pfam10420 (122 - 213)

FN3

FN3: cd00063 (232 - 269)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

interleukin-12 subunit beta

  • interleukin-12 p40

Recombinant Il12b Proteins

Cat. No. Product Name Accession Purity
HY-P7370 IL-12 Protein, Rat (CHO) Q9R103 (R23-S215)&E9PU71 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72598 IL-12 Protein, Rat (HEK293, His) Q9R103 (R23-S215)&Q9R278 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73164 IL-12 beta Protein, Rat (HEK293, His) G3V9Y5 (M1-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73195 IL-23 Protein, Rat (HEK293, His) NP_569094.1 (V22-A196) & EDM04146.1 (M23-S335) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74835 IL-12 beta Protein, Rat (HEK293, Fc) XP_006246209.1 (M23-S335) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06680 IL12B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06681 Il12b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06682 Il12b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174617 Human IL23A mRNA / Unkown
HY-174641 Human IL12B mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il12b NCBI NCBI:3593