Wnt5a - Wnt family member 5A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64566

Summary

Predicted to enable protein domain specific binding activity and signaling receptor binding activity. Involved in several processes, including estrous cycle; positive regulation of neuron projection arborization; and response to testosterone. Acts upstream of or within Wnt signaling pathway, planar cell polarity pathway. Located in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt5a Products (1)

mRNA Protein Name
NM_022631.3 NP_072153.2 protein Wnt-5a precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IDA
IDA: Inferred from direct assay
15537637 RGD
involved in cell differentiation IEP
IEP: Inferred from expression pattern
16780995 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
20126574 RGD
involved in lung alveolus development IEP
IEP: Inferred from expression pattern
17911382 RGD
involved in modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
26311509 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26311509 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
16909041 RGD
involved in positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15327998 RGD
involved in positive regulation of dendrite extension IMP
IMP: Inferred from mutant phenotype
25424568 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
25424568 RGD
involved in positive regulation of neuron projection arborization IGI
IGI: Inferred from genetic interaction
25424568 RGD
involved in prostate gland development IEP
IEP: Inferred from expression pattern
19389372 RGD
involved in regulation of postsynaptic specialization assembly IDA
IDA: Inferred from direct assay
19332546 RGD
involved in regulation of postsynaptic specialization assembly IEP
IEP: Inferred from expression pattern
19332546 RGD
involved in regulation of postsynaptic specialization assembly IMP
IMP: Inferred from mutant phenotype
19332546 RGD
involved in regulation of synaptic signaling by nitric oxide EXP
EXP: Inferred from Experiment
26311509 RGD
involved in regulation of synaptic signaling by nitric oxide IDA
IDA: Inferred from direct assay
26311509 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16551644 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
17911382 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
17911382 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20006014 RGD
involved in response to quercetin IEP
IEP: Inferred from expression pattern
28032729 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
17218409 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
26311509 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
26311509 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16243537 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
26311509 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19332546 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19332546 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-5a

  • Wnt-5a protein

  • wingless-related MMTV integration site 5A

  • wingless-type MMTV integration site 5A

  • wingless-type MMTV integration site family, member 5A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P1416A Foxy-5 TFA Agonist 99.17% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99201 Zilovertamab Inhibitor 98.21% Phase 3

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123071 Box5 Antagonist 98.81% Unkown
HY-P1416 Foxy-5 Agonist 99.02% Unkown
HY-123071A Box5 TFA Antagonist 99.50% Unkown
HY-12557 γ-Glutamylvaline 99.94% Unkown
HY-116553 FzM1 Inhibitor 98.72% Unkown
HY-N0836 Jervine 99.28% Unkown
HY-RS15837 WNT5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11867 UM206_L Activator / Unkown
HY-P11867A UM206_C Activator / Unkown
HY-N0836A Jervine hydriodide / Unkown
HY-P5171 MDGCEL Antagonist / Unkown
HY-RS17616 Wnt5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24076 Wnt5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt5a NCBI NCBI:7474