Htra2 - HtrA serine peptidase 2 Gene

Also Known as Omi; mnd2; Prss25

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64704

Summary

Enables peptidase activity. Involved in several processes, including cellular response to oxidative stress; negative regulation of Mitophagy in response to mitochondrial depolarization; and positive regulation of apoptotic process. Acts upstream of or within several processes, including adult walking behavior; intrinsic apoptotic signaling pathway; and nervous system development. Located in cytoplasmic side of plasma membrane and mitochondrion. Part of CD40 receptor complex. Is expressed in several structures, including gut; nervous system; reproductive system; thymus; and trachea. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Htra2 Products (1)

mRNA Protein Name
NM_019752.3 NP_062726.3 serine protease HTRA2, mitochondrial
Protein Preferred Names Protein Names

serine protease HTRA2, mitochondrial

  • high temperature requirement protein A2

  • motor neuron degeneration 2

  • omi stress-regulated endoprotease

  • protease, serine, 25

  • serine protease 25

  • serine protease OMI

  • serine proteinase OMI

Htra2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Htra2 Q9JIY5 Mpv17l Mus musculus Q99MS3-1
Anti Tag CoIP
18772386
Intra
Htra2 Q9JIY5 Mpv17l Mus musculus Q99MS3-3
Anti Tag CoIP
18772386
Intra
Htra2 Q9JIY5 Mpv17l Mus musculus Q99MS3
Anti Bait CoIP
18772386
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125959 Ucf-101 Inhibitor 99.65% Unkown
HY-RS06487 HTRA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20958 Htra2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27475 Htra2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htra2 NCBI NCBI:27429