Ephx2 - epoxide hydrolase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65030

Summary

Enables Epoxide Hydrolase activity; magnesium ion binding activity; and Phosphatase activity. Involved in several processes, including linoleic acid metabolic process; prostaglandin production involved in inflammatory response; and sensory perception of pain. Located in cytosol and peroxisome. Used to study cerebral infarction; hypertension; and pulmonary hypertension. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (Epoxide Hydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ephx2 Products (1)

mRNA Protein Name
NM_022936.1 NP_075225.1 bifunctional epoxide hydrolase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables epoxide hydrolase activity IDA
IDA: Inferred from direct assay
8349641 RGD
enables magnesium ion binding IMP
IMP: Inferred from mutant phenotype
12574508 RGD
enables phosphatase activity IDA
IDA: Inferred from direct assay
12574508 RGD
Biological Process GO Annotation Evidence References Source
involved in epoxide metabolic process IDA
IDA: Inferred from direct assay
21217101 RGD
involved in linoleic acid metabolic process IMP
IMP: Inferred from mutant phenotype
16962614 RGD
involved in positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
11882632 RGD
involved in prostaglandin production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
16962614 RGD
involved in response to 3-methylcholanthrene IEP
IEP: Inferred from expression pattern
19889059 RGD
Cellular Component GO Annotation Evidence References Source
located in peroxisome IDA
IDA: Inferred from direct assay
3181162 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional epoxide hydrolase 2

  • CEH

  • SEH

  • cytosolic epoxide hydrolase

  • epoxide hydratase

  • epoxide hydrolase 2, cytoplasmic

  • soluble epoxide hydrolase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159157 Anti-inflammatory agent 92 Inhibitor / Unkown
HY-187425 PROTAC sEH degrader-5 Degrader / Unkown
HY-RS04439 EPHX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18273 Ephx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24751 Ephx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ephx2 NCBI NCBI:2053