Exosc3 - exosome component 3 Gene

Also Known as Rrp40; 2310005D06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66362

Summary

Predicted to enable RNA binding activity. Involved in isotype switching. Acts upstream of or within positive regulation of isotype switching. Predicted to be located in cytoplasm; nuclear lumen; and transcriptionally active chromatin. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1B. Orthologous to human EXOSC3 (exosome component 3). [provided by Alliance of Genome Resources, Apr 2022]

Exosc3 Products (2)

mRNA Protein Name
NM_001362788.1 NP_001349717.1 exosome complex component RRP40 isoform 2
NM_025513.4 NP_079789.1 exosome complex component RRP40 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in isotype switching IMP
IMP: Inferred from mutant phenotype
21255825 MGI
acts upstream of or within positive regulation of isotype switching IMP
IMP: Inferred from mutant phenotype
21255825 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

exosome complex component RRP40

  • exosome complex exonuclease RRP40

  • ribosomal RNA-processing protein 40

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139059 ERD03 Inhibitor 99.98% Unkown
HY-RS04599 EXOSC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21124 Exosc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27643 Exosc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Exosc3 NCBI NCBI:51010