Atg4b - autophagy related 4B, cysteine peptidase Gene

Also Known as Apg4b; Autl1; Atg4bl; MmAPG4B; 2510009N07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66615

Summary

Enables peptidase activity. Involved in autophagosome assembly and cellular response to starvation. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; gut; lymph node; and sensory organ. Orthologous to human ATG4B (Autophagy related 4B cysteine peptidase). [provided by Alliance of Genome Resources, Apr 2022]

Atg4b Products (2)

mRNA Protein Name
NM_001368266.1 NP_001355195.1 cysteine protease ATG4B isoform 2
NM_174874.4 NP_777363.1 cysteine protease ATG4B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
29458288 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
14530254 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14530254 MGI
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
25578879 MGI
involved in autophagy IMP
IMP: Inferred from mutant phenotype
20577052 MGI
involved in cellular response to starvation IMP
IMP: Inferred from mutant phenotype
25578879 MGI
involved in otolith mineralization completed early in development IMP
IMP: Inferred from mutant phenotype
20577052 MGI
involved in protein delipidation IDA
IDA: Inferred from direct assay
29458288 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14530254 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cysteine protease ATG4B

  • APG4 (ATG4) autophagy-related homolog B

  • AUT-like 1, cysteine endopeptidase

  • autophagin 1

  • autophagy-related 4B

  • autophagy-related cysteine endopeptidase 1

  • autophagy-related protein 4 homolog B

  • cysteine protease involved in autophagy APG4-B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125169 NSC 185058 Inhibitor 99.90% Unkown
HY-112818 S130 99.43% Unkown
HY-123967 RNF5 inhibitor inh-02 99.91% Unkown
HY-112711 LV-320 Inhibitor 95.0% Unkown
HY-170515 RNF5 agonist 1 Agonist 99.05% Unkown
HY-144636 Atg4B-IN-2 Inhibitor 98.03% Unkown
HY-W287569 STK683963 99.41% Unkown
HY-163193 MJO445 Inhibitor / Unkown
HY-181936 Atg4B activator-1 / Unkown
HY-184717 Atg4B-IN-3 Inhibitor / Unkown
HY-RS01149 ATG4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16929 Atg4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23372 Atg4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atg4b NCBI NCBI:23192