Mcub - mitochondrial calcium uniporter dominant negative beta subunit Gene

Also Known as Ccdc109b; 9030408N13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66815

Summary

Enables Calcium Channel Inhibitor activity. Involved in mitochondrial calcium ion homeostasis and mitochondrial calcium ion transmembrane transport. Located in mitochondrion. Is intrinsic component of membrane. Part of Calcium Channel complex. Orthologous to human MCUB (mitochondrial calcium uniporter dominant negative subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Mcub Products (2)

mRNA Protein Name
NM_001293644.2 NP_001280573.2 calcium uniporter regulatory subunit MCUb, mitochondrial isoform 2
NM_025779.4 NP_080055.3 calcium uniporter regulatory subunit MCUb, mitochondrial isoform1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel inhibitor activity IDA
IDA: Inferred from direct assay
23900286 MGI
NOT enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
23900286 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23900286 MGI
Biological Process GO Annotation Evidence References Source
involved in mitochondrial calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
23900286 MGI
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
23900286 MGI
involved in negative regulation of calcium import into the mitochondrion IDA
IDA: Inferred from direct assay
31533452 MGI
involved in positive regulation of skeletal muscle satellite cell differentiation IMP
IMP: Inferred from mutant phenotype
34726954 MGI
involved in regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
34726954 MGI
involved in skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
34726954 MGI
Cellular Component GO Annotation Evidence References Source
part of calcium channel complex IDA
IDA: Inferred from direct assay
23900286 MGI
located in membrane IDA
IDA: Inferred from direct assay
23900286 MGI
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
23900286 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcium uniporter regulatory subunit MCUb, mitochondrial

  • coiled-coil domain containing 109B

  • coiled-coil domain-containing protein 109B

  • mitochondrial calcium uniporter regulatory subunit MCUb

Mcub Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mcub Q810S1 Mcu Mus musculus Q3UMR5
Anti Tag CoIP
23900286
Intra
Mcub Q810S1 Mcu Mus musculus Q3UMR5
FRET
23900286
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08253 MCUB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17019 Areg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20771 Mcub Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27285 Mcub Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcub NCBI NCBI:55013