MCUB - mitochondrial calcium uniporter dominant negative subunit beta Gene

Homo sapiens

Also known as CCDC109B

Gene ID: 55013 | Gene type: protein coding

About MCUB

This gene has 5 transcripts (splice variants), 223 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 15.3), appendix (RPKM 10.9) and 21 other tissues.

Summary

Predicted to enable Calcium Channel Inhibitor activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Located in mitochondrion and nucleoplasm. Is integral component of mitochondrial inner membrane. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022]

MCUB Products(1)

mRNA	Protein	Name
NM_017918.5	NP_060388.2	calcium uniporter regulatory subunit MCUb, mitochondrial

MCUB Protein Structure

MCU

0
100
200
300
336 a.a.

Protein Preferred Names

Protein Names

calcium uniporter regulatory subunit MCUb, mitochondrial

coiled-coil domain containing 109B

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08253	MCUB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MCUB	RGD	RGD:1305326
Mus musculus	MCUB	MGD	MGI:1914065
Macaca mulatta	MCUB	VGNC	VGNC:107182
Bos taurus	MCUB	VGNC	VGNC:31326
Canis familiaris	MCUB	VGNC	VGNC:43097
Felis catus	MCUB	VGNC	VGNC:63422