MCUB - mitochondrial calcium uniporter dominant negative subunit beta Gene

Also Known as CCDC109B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55013

About MCUB

This gene has 5 transcripts (splice variants), 223 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 15.3), appendix (RPKM 10.9) and 21 other tissues.

Summary

Predicted to enable Calcium Channel Inhibitor activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Located in mitochondrion and nucleoplasm. Is integral component of mitochondrial inner membrane. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022]

MCUB Products (1)

mRNA Protein Name
NM_017918.5 NP_060388.2 calcium uniporter regulatory subunit MCUb, mitochondrial

MCUB Protein Structure

MCU

MCU: Mitochondrial calcium uniporter (94 - 306)

  • 0
  • 100
  • 200
  • 300
  • 336 a.a.
Protein Preferred Names Protein Names

calcium uniporter regulatory subunit MCUb, mitochondrial

  • coiled-coil domain containing 109B

MCUB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MCUB Q9NWR8 SETDB1 Homo sapiens Q15047
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08253 MCUB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17019 Areg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20771 Mcub Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27285 Mcub Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MCUB RGD RGD:1305326
Mus musculus MCUB MGD MGI:1914065
Macaca mulatta MCUB VGNC VGNC:107182
Bos taurus MCUB VGNC VGNC:31326
Canis familiaris MCUB VGNC VGNC:43097
Felis catus MCUB VGNC VGNC:63422
Others MCUB NCBI