Sdhd - succinate dehydrogenase complex, subunit D, integral membrane protein Gene

Also Known as QPs3; cybS; CII-4; AVLL5809; PRO19626; 3110001M13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66925

Summary

Enables Succinate Dehydrogenase (ubiquinone) activity. Acts upstream of or within cellular response to hypoxia and regulation of Catecholamine secretion. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHD (Succinate Dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Apr 2022]

Sdhd Products (1)

mRNA Protein Name
NM_025848.3 NP_080124.1 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables succinate dehydrogenase (quinone) activity IMP
IMP: Inferred from mutant phenotype
15572694 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
15572694 MGI
acts upstream of or within regulation of catecholamine secretion IMP
IMP: Inferred from mutant phenotype
15572694 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
16120479 MGI
is active in mitochondrion IMP
IMP: Inferred from mutant phenotype
15572694 MGI
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
15572694 MGI
part of respiratory chain complex II (succinate dehydrogenase) IDA
IDA: Inferred from direct assay
16120479 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

  • succinate dehydrogenase complex subunit D

  • succinate-ubiquinone oxidoreductase cytochrome b small subunit

  • succinate-ubiquinone reductase membrane anchor subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21431 Sdhd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12595 SDHD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27949 Sdhd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sdhd NCBI NCBI:6392