SQLE - squalene epoxidase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6713

About SQLE

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:124,998,505-125,022,283 (from NCBI)

This gene has 6 transcripts (splice variants) and 213 orthologues. Broad expression in testis (RPKM 28.6), esophagus (RPKM 19.3) and 22 other tissues.

Summary

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting Enzymes in this pathway. [provided by RefSeq, Jul 2008]

SQLE Products (1)

mRNA Protein Name
NM_003129.4 NP_003120.2 squalene monooxygenase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables FAD binding IDA
IDA: Inferred from direct assay
30626872 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29765154 GOA
enables squalene monooxygenase activity IDA
IDA: Inferred from direct assay
30626872 GOA
Biological Process GO Annotation Evidence References Source
involved in lipid droplet formation IMP
IMP: Inferred from mutant phenotype
29765154 GOA
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
29765154 GOA
involved in sterol biosynthetic process IDA
IDA: Inferred from direct assay
30626872 GOA
Cellular Component GO Annotation Evidence References Source
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
30626872 GOA
located in membrane IDA
IDA: Inferred from direct assay
30626872 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SQLE Protein Structure

Pyr_redox

Pyr_redox: Pyridine nucleotide-disulphide oxidoreductase (126 - 154)

SE

SE: Squalene epoxidase (277 - 548)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
Protein Preferred Names Protein Names

squalene monooxygenase

  • SE

SQLE Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SQLE Q14534 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SQLE Q14534 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SQLE Q14534 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SQLE Q14534 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
SQLE Q14534 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
SQLE Q14534 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
SQLE Q14534 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
SQLE Q14534 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SQLE Q14534 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tinea Corporis

  • Dermatophytosis Of The Body

  • Dermatophytosis Of The Trunk
Tinea Cruris

  • Dermatophytosis Of Groin & Perianal Area

  • Dermatophytosis Of Groin And Perianal Area

  • Dhobie Itch

  • Tinea Of Perianal Region
Tinea Pedis

  • Athlete'S Foot

  • Dermatophytosis Of Foot

  • Ringworm Of Foot

  • Moccasin Foot
Tinea Unguium

  • Dermatophytosis Of Nail

  • Onychomycosis Due To Dermatophyte

  • Cellulitis And Abscess

  • Cellulitis And Abscess Of Buttock

  • Cellulitis And Abscess Of Face

  • Cellulitis And Abscess Of Finger

  • Cellulitis And Abscess Of Finger And Toe

  • Cellulitis And Abscess Of Gluteal Region

  • Cellulitis And Abscess Of Trunk

  • Cellulitis And Abscess Of Upper Arm And Forearm

  • Dermatophytic Onychia

  • Dermatophytic Onychomycosis

  • Onychomycosis

  • Ringworm Of Nails

  • Tinea Of Nail
Tinea Capitis

  • Dermatophytosis Of Scalp

  • Scalp Ringworm

  • Dermatophytosis Of Scalp Or Beard

  • Tinea Capitis Due To Trichophyton Rubrum

  • Trichophyton Rubrum Tinea Capitis
Tinea Manuum

  • Tinea Manus

  • Dermatophytosis Of Hand
Dermatophytosis

  • Tinea

  • Dermatophytosis, Unspecified

  • Ringworm

  • Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

  • Cutaneous Mycosis

  • Dermal Mycosis

  • Superficial Mycosis, Unspecified

  • Fungus Infection Of Skin

  • Skin Mycosis

  • Dermatitis Fungoid

  • Fungal Dermatitis

  • Fungal Dermatosis

  • Mycotic Infection Of Skin
Candida Glabrata

  • Torulopsis Glabrata
Tinea Barbae

  • Dermatophytosis Of Beard
Humeroradial Synostosis

  • Humero-Radial Fusion

  • Humero-Radial Synostosis

  • Ramer Ladda Syndrome
Superficial Mycosis

  • Piedra

  • Steroid-Modified Tinea Infection
Antley-Bixler Syndrome

  • Trapezoidocephaly Synostosis Syndrome

  • Trapezoidocephaly-Synostosis Syndrome

  • Antley Bixler Syndrome

  • Multisynostotic Osteodysgenesis With Long Bone Fractures

  • Osteodysgenesis, Multisynostotic With Fractures

  • Antley-Bixler Syndrome, Autosomal Dominant

  • Antley-Bixler Syndrome Phenotype
Smith-Lemli-Opitz Syndrome

  • SLOS

  • Rsh Syndrome

  • 7-Dehydrocholesterol Reductase Deficiency

  • Slo Syndrome

  • Rutledge Lethal Multiple Congenital Anomaly Syndrome

  • Lethal Acrodysgenital Syndrome

  • Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung

  • Smith-Opitz-Inborn Syndrome

  • Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung

  • Smith Lemli Opitz Syndrome

  • Smith-Lemli-Opitz Syndrome, Type Ii
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160093 SQLE-IN-1 99.21% Unkown
HY-RS13743 SQLE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153774 UBA6-IN-1 Inhibitor / Unkown
HY-RS17967 Sqle Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24438 Sqle Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SQLE VGNC VGNC:77875
Felis catus SQLE VGNC VGNC:65668
Rattus norvegicus SQLE RGD RGD:3755
Mus musculus SQLE MGD MGI:109296
Canis familiaris SQLE VGNC VGNC:46786
Bos taurus SQLE VGNC VGNC:35264
Others SQLE NCBI