Cdt1 - chromatin licensing and DNA replication factor 1 Gene

Also Known as DUP; Ris2; 2610318F11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67177

Summary

Enables DNA binding activity. Involved in DNA replication checkpoint signaling and regulation of DNA-dependent DNA replication initiation. Acts upstream of or within regulation of nuclear cell cycle DNA replication. Located in nucleus. Is expressed in adrenal medulla; brain ventricular layer; dorsal root ganglion; liver; and trunk mesenchyme derived from neural crest. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdt1 Products (1)

mRNA Protein Name
NM_026014.3 NP_080290.3 DNA replication factor Cdt1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12192004 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12192004 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA replication checkpoint signaling IDA
IDA: Inferred from direct assay
12192004 MGI
involved in regulation of DNA-templated DNA replication initiation IDA
IDA: Inferred from direct assay
12192004 MGI
acts upstream of or within regulation of nuclear cell cycle DNA replication IDA
IDA: Inferred from direct assay
11850834 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14993212 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA replication factor Cdt1

  • double parked homolog

  • retroviral insertion site 2 protein

  • retroviral integration site 1

  • retroviral integration site 2

Cdt1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cdt1 Q8R4E9 Gmnn Mus musculus O88513
Y2H
12192004
Intra
Cdt1 Q8R4E9 Mcm6 Mus musculus P97311
Y2H
12192004
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-128586 TAS4464 99.21% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128586A TAS4464 hydrochloride 98.91% Unkown
HY-171180 AF615 99.55% Unkown
HY-RS02427 CDT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20704 Cdt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27215 Cdt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdt1 NCBI NCBI:81620