Kat8 - K(lysine) acetyltransferase 8 Gene

Also Known as MOF; Myst1; MYST-1; D7Ertd629e; 2010203C02Rik; 5830450F21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67773

Summary

Enables enzyme binding activity and Histone Acetyltransferase activity (H4-K16 specific). Involved in histone H4-K16 acetylation. Located in kinetochore and nuclear matrix. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; limb; nervous system; and respiratory system. Orthologous to human KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]

Kat8 Products (2)

mRNA Protein Name
NM_001360699.1 NP_001347628.1 histone acetyltransferase KAT8 isoform 2
NM_026370.2 NP_080646.1 histone acetyltransferase KAT8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetyltransferase activity IDA
IDA: Inferred from direct assay
19578370 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
19578370 MGI
enables histone H4K16 acetyltransferase activity IDA
IDA: Inferred from direct assay
24898753 MGI
enables histone H4K16 acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
23523075 MGI
enables peptide-lysine-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
30842237 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
23523075 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17335777 MGI
Biological Process GO Annotation Evidence References Source
involved in dosage compensation by inactivation of X chromosome IDA
IDA: Inferred from direct assay
24842875 MGI
involved in negative regulation of type I interferon production IDA
IDA: Inferred from direct assay
30842237 MGI
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
31794431 MGI
involved in oogenesis IDA
IDA: Inferred from direct assay
28506985 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
24842875 MGI
involved in positive regulation of skeletal muscle satellite cell differentiation IDA
IDA: Inferred from direct assay
34059674 MGI
involved in post-embryonic hemopoiesis IMP
IMP: Inferred from mutant phenotype
27827827 MGI
involved in regulation of mitochondrial transcription IDA
IDA: Inferred from direct assay
27768893 MGI
Cellular Component GO Annotation Evidence References Source
part of MSL complex IDA
IDA: Inferred from direct assay
24842875 MGI
part of MSL complex IMP
IMP: Inferred from mutant phenotype
23523075 MGI
part of NSL complex IDA
IDA: Inferred from direct assay
24842875 MGI
is active in chromosome IDA
IDA: Inferred from direct assay
24898753 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
14519686 MGI
is active in mitochondrion IDA
IDA: Inferred from direct assay
37813994 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
27768893 MGI
located in nuclear matrix IDA
IDA: Inferred from direct assay
21746928 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
28506985 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone acetyltransferase KAT8

  • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1

  • MYST histone acetyltransferase 1

  • histone acetyltransferase Myst1

  • lysine acetyltransferase 8

  • probable histone acetyltransferase MYST1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15887 MG 149 99.60% Unkown
HY-W015239 KAT8-IN-1 99.61% Unkown
HY-149302 MC4033 98.26% Unkown
HY-153604 MC4171 Inhibitor 99.37% Unkown
HY-168428 CHI-KAT8i5 98.00% Unkown
HY-RS17587 Kat8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07084 KAT8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24047 Kat8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W614583 4-Aminonaphthalen-1-yl acetate Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kat8 NCBI NCBI:84148