Tnfsf13 - tumor necrosis factor (ligand) superfamily, member 13 Gene

Also Known as April; Tall2; Trdl1; Tnlg7b; 2310026N09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69583

Summary

Predicted to enable receptor ligand activity. Acts upstream of or within immunoglobulin mediated immune response; positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and positive regulation of cell population proliferation. Located in external side of plasma membrane. Is expressed in central nervous system; renal vasculature; retina outer nuclear layer; and superior cervical ganglion. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma. Orthologous to human TNFSF13 (TNF Superfamily member 13). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf13 Products (2)

mRNA Protein Name
NM_001159505.1 NP_001152977.1 tumor necrosis factor ligand superfamily member 13 isoform 2
NM_023517.2 NP_076006.2 tumor necrosis factor ligand superfamily member 13 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of germinal center formation IMP
IMP: Inferred from mutant phenotype
14988498 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
14988498 MGI
acts upstream of or within immunoglobulin production in mucosal tissue IMP
IMP: Inferred from mutant phenotype
14988498 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10973284 MGI
acts upstream of or within positive regulation of germinal center formation IMP
IMP: Inferred from mutant phenotype
14988498 MGI
acts upstream of or within positive regulation of isotype switching to IgA isotypes IMP
IMP: Inferred from mutant phenotype
14988498 MGI
acts upstream of or within regulation of immune response IMP
IMP: Inferred from mutant phenotype
14988498 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
14729948 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 13

  • a proliferation-inducing ligand

  • tumor necrosis factor ligand 7b

Recombinant Tnfsf13 Proteins

Cat. No. Product Name Accession Purity
HY-P7320 APRIL/TNFSF13 Protein, Mouse Q9D777 (R50-L241) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7538 APRIL/TNFSF13 Protein, Mouse (HEK293, Fc) Q9D777 (A96-K240) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990070 Zigakibart Inhibitor 99.30% Phase 3

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14823 TNFSF13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14824 TNFSF13B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17086 Tnfsf13b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17239 Tnfsf13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23530 Tnfsf13b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23693 Tnfsf13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992101 Aritinercept Inhibitor 99.9% Unkown
HY-P992479 UBP1213 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfsf13 NCBI NCBI:8741