TNFSF13 - TNF superfamily member 13 Gene

Homo sapiens

Also known as APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715

Gene ID: 8741 | Gene type: protein coding

About TNFSF13

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,558,282-7,561,601 (from NCBI)

This gene has 9 transcripts (splice variants), 97 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 37.5), gall bladder (RPKM 25.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF Receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce Apoptosis through its interaction with other TNF Receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

TNFSF13 Products(6)

mRNA	Protein	Name
NM_001198622.2	NP_001185551.1	tumor necrosis factor ligand superfamily member 13 isoform delta
NM_001198623.2	NP_001185552.1	tumor necrosis factor ligand superfamily member 13 isoform zeta
NM_001198624.2	NP_001185553.1	tumor necrosis factor ligand superfamily member 13 isoform eta
NM_003808.4	NP_003799.1	tumor necrosis factor ligand superfamily member 13 isoform alpha precursor
NM_172087.3	NP_742084.1	tumor necrosis factor ligand superfamily member 13 isoform beta precursor
NM_172088.4	NP_742085.1	tumor necrosis factor ligand superfamily member 13 isoform gamma

TNFSF13 Protein Structure

TNF

0
100
200
250 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor ligand superfamily member 13

TNF- and APOL-related leukocyte expressed ligand 2

Recombinant TNFSF13 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70733	APRIL/TNFSF13 Trimer Protein, Human (HEK293, Flag-His)	O75888 (K112-L250)	≥95%
HY-P700016AF	Animal-Free APRIL/TNFSF13 Protein, Human (His)	O75888 (A105-L250)	≥95%
HY-P700661	APRIL/TNFSF13 Protein, Human (Biotinylated, HEK293, Flag, His-Avi)	O75888-1 (K112-L250)	≥95%

Related Diseases

Diseases

Alias

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990070	Zigakibart	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14823	TNFSF13 Human Pre-designed siRNA Set A		/	Unkown
HY-RS14824	TNFSF13B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNFSF13	VGNC	VGNC:55879
Canis familiaris	TNFSF13	VGNC	VGNC:97225
Mus musculus	TNFSF13	MGD	MGI:1916833
Rattus norvegicus	TNFSF13	RGD	RGD:1305871
Macaca fascicularis	TNFSF13	NCBI
Macaca mulatta	TNFSF13	NCBI
Others	TNFSF13	NCBI

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