TPI1 - triosephosphate isomerase 1 Gene

Also Known as TIM; TPI; TPID; HEL-S-49

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7167

About TPI1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,867,420-6,870,948 (from NCBI)

This gene has 10 transcripts (splice variants), 300 orthologues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 181.7), brain (RPKM 179.1) and 25 other tissues.

Summary

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

TPI1 Products (3)

mRNA	Protein	Name
NM_000365.6	NP_000356.1	triosephosphate isomerase isoform 1
NM_001159287.1	NP_001152759.1	triosephosphate isomerase isoform 2
NM_001258026.2	NP_001244955.1	triosephosphate isomerase isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20849852	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18562316	GOA
enables triose-phosphate isomerase activity	IDA IDA: Inferred from direct assay	18562316	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19725078	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glyceraldehyde-3-phosphate biosynthetic process	IDA IDA: Inferred from direct assay	18562316	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPI1 Protein Structure

TIM

0
100
200
286 a.a.

Protein Preferred Names	Protein Names
triosephosphate isomerase	epididymis secretory protein Li 49

TPI1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TPI1	P60174	PCNA	Homo sapiens	P12004	Far-WB	20849852
Intra	TPI1	P60174	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	TPI1	P60174	TERF1	Homo sapiens	P54274	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TPI1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71364	TIM Protein, Human (His)	P60174 (M1-Q249)	≥ 95%, as determined by reducing SDS-PAGE.

TPI1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810577	Triosephosphate isomerase Antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat, Monkey
HY-P810578	Triosephosphate isomerase Antibody (YA9842)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat, Monkey
HY-P82321	Triosephosphate Isomerase Antibody (YA2066)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Triosephosphate Isomerase Deficiency	TPID Triose Phosphate-Isomerase Deficiency Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency Tpi Deficiency Triose Phosphate Isomerase Deficiency Deficiency Of Phosphotriose Isomerase Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency
Giardiasis	Beaver Feaver Infection By Giardia Lamblia Lambliasis Giardia Lamblia Dysentery Giardial Diarrhoea Lamblia Dysentery Giardia Duodenalis Dysentery Giardia Intestinalis Dysentery
Congenital Hemolytic Anemia	Anemia Hemolytic Congenital Anemia, Hemolytic, Congenital Congenital Hemolytic Anaemia Hereditary Hemolytic Anaemia Hereditary Hemolytic Anemia
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Phosphoglycerate Kinase 1 Deficiency	Pgk1 Deficiency Glycogen Storage Disease Due To Phosphoglycerate Kinase 1 Deficiency Phosphoglycerate Kinase Deficiency Pgk Deficiency Glycogenosis Due To Phosphoglycerate Kinase 1 Deficiency Gsd Due To Phosphoglycerate Kinase 1 Deficiency Deficiency Of Phosphoglycerate Kinase PGK1D Deficiency, Phosphoglycerate Kinase 1
Endocarditis
Schistosomiasis	Katayama Fever Bilharzia Bilharziasis Schistosomiasis Mansoni Blood Fluke Schistosoma Mansoni Infection Snail Fever Acute Schistosomiasis Schistosomiasis Manson Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis] Intestinal Schistosomiasis Nos Intestinal Schistosomiasis Egyptian Splenomegaly Bilharziasis Of Intestine Schistosomal Dysentery Schistosomiasis Of Colon Asiatic Schistosomiasis Eastern Schistosomiasis Schistosoma Japonicum Infection Schistosomiasis Japonicum Katayama Disease Katayama Syndrome Oriental Schistosomiasis
Intestinal Disaccharidase Deficiency	Disaccharidase Deficiency
Microsporidiosis	Infection By Microspora Microsporidiasis Infection By Microsporea Infection By Microsporida Intestinal Microsporidiosis Microsporidia Infection Infection By Microsporidia
Clostridium Difficile Colitis	Pseudomembranous Colitis Colitis Pseudomembranous Enterocolitis, Pseudomembranous Pseudomembranous Enterocolitis Clostridium Difficile Infection
Cyclosporiasis	Cyclosporosis Cyclospora Infection
Shrimp Allergy
Crustacean Allergy
Cryptosporidiosis	Cryptosporidial Gastroenteritis Intestinal Cryptosporidiosis Infection By Cryptosporidium Gastroenteritis Due To Cryptosporidium Cryptosporidial Infection
Toxic Megacolon	Megacolon, Toxic Toxic Dilatation Of Colon Toxic Functional Megacolon
Anemia, Congenital Dyserythropoietic, Type Ia	Congenital Dyserythropoietic Anemia Type I Cda I CDAN1A Congenital Dyserythropoietic Anemia Type 1 Congenital Dyserythropoietic Anemia Type Ia Congenital Dyserythropoietic Anemia, Type I Anemia, Congenital Dyserythropoietic, Type I Cda Type 1 Cda Type I Cda Ia Dyserythropoietic Anemia, Congenital Type 1 Anemia, Congenital Dyserythropoietic, Type 1a Dyserythropoietic Anemia, Congenital, Type Ia Cda, Type Ia Congenital Dyserythropoietic Anaemia Type 1 Congenital Dyserythropoietic Anaemia Type I Anemia, Dyserythropoietic, Congenital Type 1 Type I Congenital Dyserythropoietic Anemia Anemia, Congenital Dyserythropoietic, 1a Anemia, Dyserythropoietic, Congenital, Type Ia
Intestinal Schistosomiasis	Schistosomiasis Japonica Schistosomiasis Mansoni Katayama Fever Schistosoma Japonicum Infection Schistosoma Mansoni Infectious Disease Schistosomiasis
Cystoisosporiasis	Isosporiasis Infection By Isospora Belli And Isospora Hominis Isosporosis Infection By Isospora Belli Or Isospora Hominis Isospora Belli Or Hominis Infection Coccidial Infestation Coccidiosis Coccidial Dysentery Intestinal Coccidiosis Nos
Epilepsy, Familial Temporal Lobe, 2	Familial Temporal Lobe Epilepsy 2 Temporal Epilepsy, Familial ETL2 Ftle Epilepsy, Familial Temporal Lobe Familial Temporal Lobe Epilepsy
Coccidiosis	Intestinal Coccidiosis Enteric Coccidiosis
Myopathy	Muscular Diseases Myopathies
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100463	TPI-1	Inhibitor	98.0%	Unkown
HY-RS14934	TPI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17377	Tpi1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23831	Tpi1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TPI1	RGD	RGD:3896
Bos taurus	TPI1	VGNC	VGNC:36250
Felis catus	TPI1	VGNC	VGNC:66475
Mus musculus	TPI1	MGD	MGI:98797
Canis familiaris	TPI1	VGNC	VGNC:47740
Others	TPI1	NCBI