VDAC1 - voltage dependent anion channel 1 Gene
Also Known as PORIN; VDAC-1
Species: Homo sapiens
About VDAC1
This gene has 7 transcripts (splice variants), 247 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 107.1), duodenum (RPKM 94.9) and 25 other tissues.
Summary
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
VDAC1 Products (20)
| mRNA | Protein | Name |
|---|---|---|
| NM_001401008.1 | NP_001387937.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401009.1 | NP_001387938.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401010.1 | NP_001387939.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401011.1 | NP_001387940.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401016.1 | NP_001387945.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401017.1 | NP_001387946.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401018.1 | NP_001387947.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401020.1 | NP_001387949.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401021.1 | NP_001387950.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401022.1 | NP_001387951.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401023.1 | NP_001387952.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| NM_001401024.1 | NP_001387953.1 | voltage-dependent anion-selective channel protein 1 isoform 2 |
| NM_001401025.1 | NP_001387954.1 | voltage-dependent anion-selective channel protein 1 isoform 3 |
| NM_001401026.1 | NP_001387955.1 | voltage-dependent anion-selective channel protein 1 isoform 4 |
| NM_001401027.1 | NP_001387956.1 | voltage-dependent anion-selective channel protein 1 isoform 5 |
| NM_001401028.1 | NP_001387957.1 | voltage-dependent anion-selective channel protein 1 isoform 6 |
| NM_001401029.1 | NP_001387958.1 | voltage-dependent anion-selective channel protein 1 isoform 7 |
| NM_001401031.1 | NP_001387960.1 | voltage-dependent anion-selective channel protein 1 isoform 7 |
| NM_001401032.1 | NP_001387961.1 | voltage-dependent anion-selective channel protein 1 isoform 7 |
| NM_003374.3 | NP_003365.1 | voltage-dependent anion-selective channel protein 1 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables ceramide binding |
IDA
IDA: Inferred from direct assay
|
31015432 | GOA |
| enables cholesterol binding |
IDA
IDA: Inferred from direct assay
|
31015432 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
18832158 | GOA |
| enables phosphatidylcholine binding |
IDA
IDA: Inferred from direct assay
|
31015432 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9843949 | GOA |
| enables protein kinase binding |
IPI
IPI: Inferred from physical interaction
|
21370995 | GOA |
| enables transmembrane transporter binding |
IPI
IPI: Inferred from physical interaction
|
25296756 | GOA |
| enables voltage-gated monoatomic anion channel activity |
IDA
IDA: Inferred from direct assay
|
8420959 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in apoptotic process |
IDA
IDA: Inferred from direct assay
|
25296756 | GOA |
| involved in epithelial cell differentiation |
IEP
IEP: Inferred from expression pattern
|
21492153 | GOA |
| involved in mitochondrial transmembrane transport |
IDA
IDA: Inferred from direct assay
|
38065946 | GOA |
| involved in monoatomic anion transport |
IDA
IDA: Inferred from direct assay
|
8420959 | GOA |
| involved in negative regulation of apoptotic process |
IMP
IMP: Inferred from mutant phenotype
|
32047033 | GOA |
| involved in negative regulation of calcium import into the mitochondrion |
IMP
IMP: Inferred from mutant phenotype
|
32047033 | GOA |
| involved in positive regulation of apoptotic process |
IDA
IDA: Inferred from direct assay
|
29907098 | GOA |
| involved in positive regulation of type 2 mitophagy |
IMP
IMP: Inferred from mutant phenotype
|
32047033 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in membrane |
IDA
IDA: Inferred from direct assay
|
27641616 | GOA |
| located in mitochondrial membrane |
IDA
IDA: Inferred from direct assay
|
31015432 | GOA |
| located in mitochondrial nucleoid |
IDA
IDA: Inferred from direct assay
|
18063578 | GOA |
| located in mitochondrial outer membrane |
IDA
IDA: Inferred from direct assay
|
7539795 | GOA |
| part of mitochondrial permeability transition pore complex |
IDA
IDA: Inferred from direct assay
|
26387735 | GOA |
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
30188326 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
25296756 | GOA |
VDAC1 Protein Structure
Porin_3: Eukaryotic porin (4 - 276)
- 0
- 100
- 200
- 283 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
voltage-dependent anion-selective channel protein 1 |
|
VDAC1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
VDAC1 | P21796 | RTL10 | Homo sapiens | Q7L3V2 | 23055042 | |
|
Intra
|
VDAC1 | P21796 | RTL10 | Homo sapiens | Q7L3V2 | 23055042 | |
|
Intra
|
VDAC1 | P21796 | APOE | Homo sapiens | P02649 | 33961781 | |
|
Intra
|
VDAC1 | P21796 | APOE | Homo sapiens | P02649 | 28514442 | |
|
Intra
|
VDAC1 | P21796 | PRDX6 | Homo sapiens | P30041 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | PRDX6 | Homo sapiens | P30041 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | VDAC2 | Homo sapiens | P45880 | 35271311 | |
|
Intra
|
VDAC1 | P21796 | VDAC2 | Homo sapiens | P45880 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | VDAC2 | Homo sapiens | P45880 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | VDAC1 | Homo sapiens | P21796 | 18832158 | |
|
Intra
|
VDAC1 | P21796 | VDAC1 | Homo sapiens | P21796 | 18832158 | |
|
Intra
|
VDAC1 | P21796 | VDAC3 | Homo sapiens | Q9Y277 | 30021884 | |
|
Intra
|
VDAC1 | P21796 | VDAC1 | Homo sapiens | P21796 | 18832158 | |
|
Intra
|
VDAC1 | P21796 | VDAC1 | Homo sapiens | P21796 | 18832158 | |
|
Intra
|
VDAC1 | P21796 | VDAC3 | Homo sapiens | Q9Y277 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | VDAC3 | Homo sapiens | Q9Y277 | 35271311 | |
|
Intra
|
VDAC1 | P21796 | SLC25A6 | Homo sapiens | P12236 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | YWHAE | Homo sapiens | P62258 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | YWHAE | Homo sapiens | P62258 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | CDK1 | Homo sapiens | P06493 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | CDK1 | Homo sapiens | P06493 | 29128334 | |
|
Intra
|
VDAC1 | P21796 | LRRK2 | Homo sapiens | Q5S007 | 21370995 | |
|
Intra
|
VDAC1 | P21796 | HK1 | Homo sapiens | P19367 | 35271311 | |
|
Intra
|
VDAC1 | P21796 | PB1 | Influenza A virus | P0C0U1 | 16201016 |
VDAC1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80369 | VDAC1 Antibody (YA016) | WB, IHC-P, ICC/IF, FC, IF-Tissue | Human, Mouse, Rat |
| HY-P86507 | VDAC1 Antibody (YA6199) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Typhoid Fever |
|
|
| Cystic Fibrosis |
|
|
| Connective Tissue Disease |
|
|
| Lung Cancer |
|
|
| Parathyroid Oncocytic Adenoma |
|
|
| 3-Methylglutaconic Aciduria, Type Iii |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Mitochondrial Myopathy |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Leber Hereditary Optic Neuropathy, Modifier Of |
|
|
| Leigh Syndrome |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Hereditary Spastic Paraplegia |
|
|
| Nervous System Disease |
|
|
| Dilated Cardiomyopathy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | VDAC1 | VGNC | VGNC:103885 |
| Mus musculus | VDAC1 | MGD | MGI:106919 |
| Rattus norvegicus | VDAC1 | RGD | RGD:621575 |
| Bos taurus | VDAC1 | VGNC | VGNC:36782 |
| Felis catus | VDAC1 | VGNC | VGNC:97681 |
| Canis familiaris | VDAC1 | VGNC | VGNC:48246 |
| Others | VDAC1 | NCBI |