VDAC1 - voltage dependent anion channel 1 Gene

Also Known as PORIN; VDAC-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7416

About VDAC1

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:133,971,871-134,114,540 (from NCBI)

This gene has 7 transcripts (splice variants), 247 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 107.1), duodenum (RPKM 94.9) and 25 other tissues.

Summary

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

VDAC1 Products (20)

mRNA Protein Name
NM_001401008.1 NP_001387937.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401009.1 NP_001387938.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401010.1 NP_001387939.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401011.1 NP_001387940.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401016.1 NP_001387945.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401017.1 NP_001387946.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401018.1 NP_001387947.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401020.1 NP_001387949.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401021.1 NP_001387950.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401022.1 NP_001387951.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401023.1 NP_001387952.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401024.1 NP_001387953.1 voltage-dependent anion-selective channel protein 1 isoform 2
NM_001401025.1 NP_001387954.1 voltage-dependent anion-selective channel protein 1 isoform 3
NM_001401026.1 NP_001387955.1 voltage-dependent anion-selective channel protein 1 isoform 4
NM_001401027.1 NP_001387956.1 voltage-dependent anion-selective channel protein 1 isoform 5
NM_001401028.1 NP_001387957.1 voltage-dependent anion-selective channel protein 1 isoform 6
NM_001401029.1 NP_001387958.1 voltage-dependent anion-selective channel protein 1 isoform 7
NM_001401031.1 NP_001387960.1 voltage-dependent anion-selective channel protein 1 isoform 7
NM_001401032.1 NP_001387961.1 voltage-dependent anion-selective channel protein 1 isoform 7
NM_003374.3 NP_003365.1 voltage-dependent anion-selective channel protein 1 isoform 1
Molecular Function GO Annotation Evidence References Source
enables ceramide binding IDA
IDA: Inferred from direct assay
31015432 GOA
enables cholesterol binding IDA
IDA: Inferred from direct assay
31015432 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
18832158 GOA
enables phosphatidylcholine binding IDA
IDA: Inferred from direct assay
31015432 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9843949 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21370995 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
25296756 GOA
enables voltage-gated monoatomic anion channel activity IDA
IDA: Inferred from direct assay
8420959 GOA
Biological Process GO Annotation Evidence References Source
involved in apoptotic process IDA
IDA: Inferred from direct assay
25296756 GOA
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
21492153 GOA
involved in mitochondrial transmembrane transport IDA
IDA: Inferred from direct assay
38065946 GOA
involved in monoatomic anion transport IDA
IDA: Inferred from direct assay
8420959 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
32047033 GOA
involved in negative regulation of calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
32047033 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
29907098 GOA
involved in positive regulation of type 2 mitophagy IMP
IMP: Inferred from mutant phenotype
32047033 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
27641616 GOA
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
31015432 GOA
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
18063578 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
7539795 GOA
part of mitochondrial permeability transition pore complex IDA
IDA: Inferred from direct assay
26387735 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
30188326 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
25296756 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VDAC1 Protein Structure

Porin_3

Porin_3: Eukaryotic porin (4 - 276)

  • 0
  • 100
  • 200
  • 283 a.a.
Protein Preferred Names Protein Names

voltage-dependent anion-selective channel protein 1

  • outer mitochondrial membrane protein porin 1

VDAC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VDAC1 P21796 RTL10 Homo sapiens Q7L3V2 23055042
Intra
VDAC1 P21796 RTL10 Homo sapiens Q7L3V2 23055042
Intra
VDAC1 P21796 APOE Homo sapiens P02649 33961781
Intra
VDAC1 P21796 APOE Homo sapiens P02649 28514442
Intra
VDAC1 P21796 PRDX6 Homo sapiens P30041 29128334
Intra
VDAC1 P21796 PRDX6 Homo sapiens P30041 29128334
Intra
VDAC1 P21796 VDAC2 Homo sapiens P45880 35271311
Intra
VDAC1 P21796 VDAC2 Homo sapiens P45880 29128334
Intra
VDAC1 P21796 VDAC2 Homo sapiens P45880 29128334
Intra
VDAC1 P21796 VDAC1 Homo sapiens P21796 18832158
Intra
VDAC1 P21796 VDAC1 Homo sapiens P21796 18832158
Intra
VDAC1 P21796 VDAC3 Homo sapiens Q9Y277 30021884
Intra
VDAC1 P21796 VDAC1 Homo sapiens P21796
NMR
18832158
Intra
VDAC1 P21796 VDAC1 Homo sapiens P21796
GMS
18832158
Intra
VDAC1 P21796 VDAC3 Homo sapiens Q9Y277 29128334
Intra
VDAC1 P21796 VDAC3 Homo sapiens Q9Y277 35271311
Intra
VDAC1 P21796 SLC25A6 Homo sapiens P12236 29128334
Intra
VDAC1 P21796 YWHAE Homo sapiens P62258 29128334
Intra
VDAC1 P21796 YWHAE Homo sapiens P62258 29128334
Intra
VDAC1 P21796 CDK1 Homo sapiens P06493 29128334
Intra
VDAC1 P21796 CDK1 Homo sapiens P06493 29128334
Intra
VDAC1 P21796 LRRK2 Homo sapiens Q5S007 21370995
Intra
VDAC1 P21796 HK1 Homo sapiens P19367 35271311
Intra
VDAC1 P21796 PB1 Influenza A virus P0C0U1 16201016
Cross: Cross-species interaction Intra: Intraspecies interaction

VDAC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80369 VDAC1 Antibody (YA016) WB, IHC-P, ICC/IF, FC, IF-Tissue Human, Mouse, Rat
HY-P86507 VDAC1 Antibody (YA6199) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Typhoid Fever
  • Typhoid

  • Enteric Fever

  • Typhoidal Salmonellosis

  • Ileotyphus

  • Infection By Salmonella Typhi

  • Typhoid Any Site

  • Typhoid Fever Any Site

  • Typhoid Infection

  • Typhoid Infection Any Site

  • Typhoid Fever Confirmed

  • Enteric Fever Nos

Cystic Fibrosis
  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis

Connective Tissue Disease
  • Connective Tissue Diseases

  • Connective Tissue Disorder

  • Abnormality Of Connective Tissue

  • Disorder Of Connective Tissue

  • Connective Tissue Disorders

Lung Cancer
  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma

Parathyroid Oncocytic Adenoma
  • Parathyroid Gland Oncocytic Adenoma

3-Methylglutaconic Aciduria, Type Iii
  • Optic Atrophy

  • 3-Methylglutaconic Aciduria Type 3

  • Costeff Syndrome

  • Mga3

  • Costeff Optic Atrophy Syndrome

  • Optic Atrophy Plus Syndrome

  • Infantile Optic Atrophy With Chorea And Spastic Paraplegia

  • 3-Methylglutaconic Aciduria Type Iii

  • Autosomal Recessive Optic Atrophy Plus Syndrome

  • Autosomal Recessive Optic Atrophy Type 3

  • Opa3 Defect

  • MGCA3

  • Mga, Type Iii

  • Iraqi Jewish Optic Atrophy Plus

  • Mga Type Iii

  • Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia

  • Iraqi-Jewish 'Optic Atrophy Plus'

  • Optic Atrophy 3, Autosomal Recessive

  • Opa3, Autosomal Recessive

  • Opa3-Related 3-Methylglutaconic Aciduria

  • Iraqi-Jewish Optic Atrophy Plus

  • Atrophy Of Optic Disc

  • 3-Alpha Methylglutaconic Aciduria Type Iii

  • Optic Atrophy 3

  • Optic Atrophy Infantile With Chorea And Spastic Paraplegia

  • Autosomal Recessive Opa3

  • Autosomal Recessive Optic Atrophy 3

  • 3-Methylglutaconic Aciduria 3

  • 3-Alpha-Methylglutaconic Aciduria Type 3

  • Optic Atrophy 3 Autosomal Recessive

  • Atrophy, Optic

  • Atrophy, Optic, Plus Syndrome

  • Optic Nerve Atrophy

  • Primary Optic Atrophy

  • Oa - [Optic Atrophy]

  • Second Cranial Nerve Atrophy

  • Second Cranium Nerve Atrophy

Parkinson Disease, Late-Onset
  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease

Mitochondrial Myopathy
  • Mitochondrial Myopathies

  • Mitochondrial Cytopathy

  • Myopathies In Mitochondrial Disorders

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Leber Hereditary Optic Neuropathy, Modifier Of
  • Leber Optic Atrophy

  • Leber Hereditary Optic Neuropathy

  • LHON

  • Leber'S Hereditary Optic Neuropathy

  • Leber Optic Atrophy, Susceptibility To

  • Leber'S Optic Atrophy

  • LOAM

  • Loas

  • Leber'S Disease

  • Leber'S Optic Neuropathy

  • Optic Atrophy, Hereditary, Leber

  • Lhon, Modifier Of

  • Optic Atrophy, Leber Type

  • Hereditary Optic Neuroretinopathy

  • Leber Hereditary Optic Atrophy

  • Loa

  • Optic Atrophy Leber Type

  • Leber Hereditary Optic Neuropathy, Modifier

  • Leber Hereditary Optic Neuropathy Susceptibility

  • Modifier Of Leber Hereditary Optic Neuropathy

  • Lebers Hereditary Optic Neuropathy

  • Leber Congenital Amaurosis

Leigh Syndrome
  • Leigh Disease

  • Infantile Subacute Necrotizing Encephalopathy

  • Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency

  • LS

  • Sne

  • Leigh'S Disease

  • Leigh Syndrome Due To Mitochondrial Complex I Deficiency

  • Necrotizing Encephalopathy, Infantile Subacute, Of Leigh

  • Subacute Necrotizing Encephalomyelopathy

  • Necrotizing Encephalopathy Infantile Subacute Of Leigh

  • Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency

  • Infantile Necrotizing Encephalomyelopathy

  • Juvenile Subacute Necrotizing Encephalomyelopathy

  • Leigh'S Necrotizing Encephalopathy

  • Subacute Necrotizing Encephalopathy

  • Juvenile Subacute Necrotizing Encephalopathy

  • Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency

  • Leigh Syndrome Due To Mitochondrial Complex V Deficiency

  • Encephalopathy, Subacute Necrotizing, Infantile

  • Encephalopathy, Subacute Necrotizing, Juvenile

  • Maternally Inherited Leigh Syndrome

  • Subacute Necrotising Encephalomyelopathy

  • Subacute Necrotising Encephalopathy

Amyotrophic Lateral Sclerosis 1
  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis

Hereditary Spastic Paraplegia
  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia

Nervous System Disease
  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder

Dilated Cardiomyopathy
  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta VDAC1 VGNC VGNC:103885
Mus musculus VDAC1 MGD MGI:106919
Rattus norvegicus VDAC1 RGD RGD:621575
Bos taurus VDAC1 VGNC VGNC:36782
Felis catus VDAC1 VGNC VGNC:97681
Canis familiaris VDAC1 VGNC VGNC:48246
Others VDAC1 NCBI