VIPR2 - vasoactive intestinal peptide receptor 2 Gene

Also Known as VPAC2; VPAC2R; VIP-R-2; VPCAP2R; PACAP-R3; DUP7q36.3; PACAP-R-3; C16DUPq36.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7434

About VIPR2

Cytogenetic location: 7q36.3 Genomic coordinates (GRCh38): 7:159,028,175-159,144,867 (from NCBI)

This gene has 4 transcripts (splice variants), 259 orthologues and 42 paralogues. Broad expression in ovary (RPKM 1.9), brain (RPKM 1.9) and 20 other tissues.

Summary

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates Adenylate Cyclase. [provided by RefSeq, Aug 2011]

VIPR2 Products (3)

mRNA Protein Name
NM_001304522.2 NP_001291451.1 vasoactive intestinal polypeptide receptor 2 isoform 2 precursor
NM_001308259.1 NP_001295188.1 vasoactive intestinal polypeptide receptor 2 isoform 3
NM_003382.5 NP_003373.2 vasoactive intestinal polypeptide receptor 2 isoform 1 precursor

VIPR2 Protein Structure

HRM

HRM: Hormone receptor domain (50 - 111)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (125 - 371)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 438 a.a.
Protein Preferred Names Protein Names

vasoactive intestinal polypeptide receptor 2

  • PACAP type III receptor

Recombinant VIPR2 Proteins

Cat. No. Product Name Accession Purity
HY-P76128 VIPR2 Protein, Human (HEK293, Fc) P41587 (E24-V126) ≥ 95%, as determined by reducing SDS-PAGE.

VIPR2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81526 VPAC2 Antibody (YA1271) IHC-P Human
HY-P81526A VPAC2 Antibody (YA1271)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Schizophrenia 16
  • SCZD16

  • Schizophrenia Susceptibility Locus, Chromosome 7q36.3-Related

  • Chromosome 7q36.3 Duplication Syndrome, 362-Kb

Gastric Leiomyoma
  • Leiomyoma Of The Stomach

Central Serous Chorioretinopathy
  • Central Serous Chorioretinopathy After Bone Marrow Transplantation

  • Central Serous Choroidopathy

  • Cscr

  • Central Serous Retinopathy

  • Central Serous Choroidoretinopathy

Holoprosencephaly
  • Holoprosencephaly Sequence

  • Hpe

  • Hpe - [Holoprosencephaly]

Myopia
  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted

Sudden Infant Death Syndrome
  • SIDS

  • Sudden Infant Death Syndrome, Susceptibility To

  • Cot Death

  • Crib Death

  • Sudden Death Of Nonspecific Cause In Infancy

  • Sudden Infant Death

  • Death, Sudden, Syndrome, Infant

Advanced Sleep Phase Syndrome
  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial

Isolated Growth Hormone Deficiency, Type Ib
  • Isolated Growth Hormone Deficiency Type Ib

  • IGHD1B

  • Ighd Ib

  • Growth Hormone Deficiency, Isolated, Type Ib

  • Congenital Ighd Type Ib

  • Congenital Isolated Gh Deficiency Type Ib

  • Congenital Isolated Growth Hormone Deficiency Type Ib

  • Dwarfism Of Sindh

  • Pituitary Dwarfism I

  • Isolated Growth Hormone Deficiency Type 1b

  • Ighd 1b

  • Growth Hormone Deficiency, Isolated, 1b

Major Depressive Disorder
  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes

Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type
  • Wilson-Turner Syndrome

  • WTS

  • Mrxs6

  • X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome

  • Mrxswt

  • Wilson-Turner X-Linked Mental Retardation Syndrome

  • Mental Retardation, X-Linked, Syndromic 6

  • Mental Retardation, X-Linked, With Gynecomastia And Obesity

  • Intellectual Disability, X-Linked, Syndromic 6

  • Intellectual Disability, X-Linked, With Gynecomastia And Obesity

  • Wilson Turner Intellectual Disability Syndrome

  • X-Linked Intellectual Disability - Gynecomastia - Obesity

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Migraine With Or Without Aura 1
  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To

Attention Deficit-Hyperactivity Disorder
  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris VIPR2 VGNC VGNC:48266
Bos taurus VIPR2 VGNC VGNC:36800
Mus musculus VIPR2 MGD MGI:107166
Rattus norvegicus VIPR2 RGD RGD:3962
Felis catus VIPR2 VGNC VGNC:66946
Macaca mulatta VIPR2 VGNC VGNC:78772
Others VIPR2 NCBI