Sirt4 - sirtuin 4 Gene

Also Known as 4930596O17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75387

Summary

Enables NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; and lipoamidase activity. Involved in several processes, including carboxylic acid metabolic process; cellular protein modification process; and regulation of cellular ketone metabolic process. Acts upstream of or within negative regulation of Insulin secretion. Located in mitochondrial inner membrane and mitochondrial matrix. Is expressed in several structures, including gonad; heart; nervous system; respiratory system; and thyroid gland. Orthologous to human SIRT4 (Sirtuin 4). [provided by Alliance of Genome Resources, Apr 2022]

Sirt4 Products (2)

mRNA Protein Name
NM_001167691.1 NP_001161163.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
NM_133760.1 NP_598521.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: Inferred from mutant phenotype
23663782 MGI
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
23746352 MGI
enables lipoamidase activity IMP
IMP: Inferred from mutant phenotype
25525879 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16959573 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
23562301 MGI
involved in glutamine metabolic process IMP
IMP: Inferred from mutant phenotype
23562301 MGI
involved in negative regulation of fatty acid oxidation IDA
IDA: Inferred from direct assay
23746352 MGI
involved in negative regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
24043310 MGI
acts upstream of or within negative regulation of insulin secretion IGI
IGI: Inferred from genetic interaction
16959573 MGI
acts upstream of or within negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
16959573 MGI
involved in peptidyl-lysine deacetylation IDA
IDA: Inferred from direct assay
23746352 MGI
involved in positive regulation of lipid biosynthetic process IDA
IDA: Inferred from direct assay
23746352 MGI
involved in regulation of glutamine family amino acid metabolic process IMP
IMP: Inferred from mutant phenotype
23562301 MGI
involved in regulation of pyruvate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
25525879 MGI
involved in tricarboxylic acid metabolic process IMP
IMP: Inferred from mutant phenotype
23562301 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
18054327 MGI
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
23746352 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
16959573 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

  • NAD-dependent protein biotinylase sirtuin-4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163316 SIRT4-IN-1 Inhibitor 99.94% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt4 NCBI NCBI:23409