Oga - O-GlcNAcase Gene

Also Known as Hy5; Mgea5; Ncoat

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76055

Summary

Predicted to enable beta-N-acetylglucosaminidase activity and Histone Acetyltransferase activity. Predicted to be involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of cellular protein metabolic process. Predicted to be located in cytosol and mitochondrion. Is expressed in brain ventricular layer; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Apr 2022]

Oga Products (5)

mRNA Protein Name
NM_001403349.1 NP_001390278.1 protein O-GlcNAcase isoform 2
NM_001403351.1 NP_001390280.1 protein O-GlcNAcase isoform 3
NM_001403352.1 NP_001390281.1 protein O-GlcNAcase isoform 4
NM_001403353.1 NP_001390282.1 protein O-GlcNAcase isoform 5
NM_023799.5 NP_076288.1 protein O-GlcNAcase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16356930 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein O-GlcNAcase

  • N-acetyl-beta-D-glucosaminidase

  • N-acetyl-beta-glucosaminidase

  • beta-N-acetylhexosaminidase

  • beta-hexosaminidase

  • bifunctional protein NCOAT

  • meningioma expressed antigen 5 (hyaluronidase)

  • meningioma-expressed antigen 5

  • nuclear cytoplasmic O-GlcNAcase a

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-144681 Ceperognastat Inhibitor 99.09% Phase 2
HY-130121 MK-8719 99.30% Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12588 Thiamet G Inhibitor 99.99% Unkown
HY-108241 (Z)-PUGNAc 99.13% Unkown
HY-156586 Egalognastat Inhibitor 99.03% Unkown
HY-139431 NAG-thiazoline Inhibitor ≥95.0% Unkown
HY-108032 Hydroxyectoin Inhibitor 98.92% Unkown
HY-131979 TP-040 98.59% Unkown
HY-144682 (2R,4R)-LY3372689 / Unkown
HY-144681A rel-Ceperognastat Inhibitor / Unkown
HY-183557 O-GlcNAcase-IN-6 Inhibitor / Unkown
HY-148240 JNJ-65355394 Inhibitor 99.84% Unkown
HY-161953 O-GlcNAcase-IN-2 Inhibitor / Unkown
HY-185146 O-GlcNAcase-IN-5 Inhibitor / Unkown
HY-176852 O-GlcNAcase-IN-3 Inhibitor / Unkown
HY-181600 O-GlcNAcase-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oga NCBI NCBI:10724