Prss8 - protease, serine 8 (prostasin) Gene

Also Known as fr; CAP1; mCAP1; 2410039E18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76560

Summary

Enables Sodium Channel regulator activity. Involved in transepithelial transport. Acts upstream of or within hair follicle development and positive regulation of sodium ion transport. Located in extracellular space and membrane raft. Is anchored component of plasma membrane and extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; forebrain; genitourinary system; and sensory organ. Used to study autosomal recessive congenital ichthyosis 4B. Orthologous to human PRSS8 (serine protease 8). [provided by Alliance of Genome Resources, Apr 2022]

Prss8 Products (2)

mRNA Protein Name
NM_001407961.1 NP_001394890.1 prostasin precursor
NM_133351.4 NP_579929.1 prostasin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sodium channel regulator activity IMP
IMP: Inferred from mutant phenotype
16822939 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of sodium ion transport IGI
IGI: Inferred from genetic interaction
16941024 MGI
involved in transepithelial transport IMP
IMP: Inferred from mutant phenotype
16822939 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
16822939 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
16822939 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostasin

  • channel activating protease 1

  • serine protease 8

Recombinant Prss8 Proteins

Cat. No. Product Name Accession Purity
HY-P77154 Prostasin/PRSS8 Protein, Mouse (sf9, His) EDL17608.1 (A30-Q289) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11259 PRSS8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18185 Prss8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24659 Prss8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prss8 NCBI NCBI:5652