Notum - notum palmitoleoyl-protein carboxylesterase Gene

Also Known as 5730593N15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77583

Summary

Enables Lipase activity and palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development; negative regulation of canonical Wnt signaling pathway; and regulation of bone mineralization. Predicted to be located in extracellular region. Is expressed in several structures, including genitourinary system; heart valve; respiratory system; sensory organ; and vibrissa. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). [provided by Alliance of Genome Resources, Apr 2022]

Notum Products (3)

mRNA Protein Name
NM_001382269.1 NP_001369198.1 palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor
NM_001382270.1 NP_001369199.1 palmitoleoyl-protein carboxylesterase NOTUM isoform 2 precursor
NM_175263.4 NP_780472.3 palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lipase activity IDA
IDA: Inferred from direct assay
30622831 MGI
enables palmitoleyl hydrolase activity IDA
IDA: Inferred from direct assay
25771893 MGI
Biological Process GO Annotation Evidence References Source
NOT involved in GPI anchor release IDA
IDA: Inferred from direct assay
25771893 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
30622831 MGI
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
25771893 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
30622831 MGI
involved in protein depalmitoleylation IDA
IDA: Inferred from direct assay
25771893 MGI
acts upstream of or within regulation of bone mineralization IDA
IDA: Inferred from direct assay
30622831 MGI
acts upstream of or within regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
30622831 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

palmitoleoyl-protein carboxylesterase NOTUM

  • notum pectinacetylesterase homolog

  • protein notum homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131034 LP-922056 Activator 99.63% Unkown
HY-147519 ARUK3001185 Activator 99.28% Unkown
HY-122832 ABC99 Inhibitor 98.48% Unkown
HY-142689 Carboxylesterase-IN-3 Inhibitor 98.27% Unkown
HY-142688 Carboxylesterase-IN-2 Inhibitor 99.91% Unkown
HY-149818 8BTC Inhibitor / Unkown
HY-182632 LP-935001 / Unkown
HY-RS09454 NOTUM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W171983 Notum-IN-1 Inhibitor / Unkown
HY-148360 Notum pectinacetylesterase-1 Inhibitor / Unkown
HY-182402 Notum-IN-2 / Unkown
HY-RS21001 Notum Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27518 Notum Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Notum NCBI NCBI:147111