NOTUM - notum, palmitoleoyl-protein carboxylesterase Gene

Also Known as hNOTUM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 147111

About NOTUM

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,952,507-81,961,187 (from NCBI)

This gene has 4 transcripts (splice variants) and 254 orthologues. Restricted expression toward placenta (RPKM 82.6).

Summary

Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

NOTUM Products (1)

mRNA Protein Name
NM_178493.6 NP_848588.3 palmitoleoyl-protein carboxylesterase NOTUM precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables palmitoleyl hydrolase activity IDA
IDA: Inferred from direct assay
25731175 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
30622831 GOA
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
25731175 GOA
involved in protein depalmitoleylation IDA
IDA: Inferred from direct assay
25731175 GOA
acts upstream of or within regulation of bone mineralization IDA
IDA: Inferred from direct assay
30622831 GOA
acts upstream of or within regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
30622831 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOTUM Protein Structure

PAE

PAE: Pectinacetylesterase (77 - 420)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
Protein Preferred Names Protein Names

palmitoleoyl-protein carboxylesterase NOTUM

  • [Wnt protein] O-palmitoleoyl-L-serine hydrolase

NOTUM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NOTUM Q6P988 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
NOTUM Q6P988 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
NOTUM Q6P988 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NOTUM Proteins

Cat. No. Product Name Accession Purity
HY-P79357 Notum Protein, Human (C330S, CHO, His) Q6P988 (S81-T451, C330S) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131034 LP-922056 Activator 99.63% Unkown
HY-147519 ARUK3001185 Activator 99.28% Unkown
HY-122832 ABC99 Inhibitor 98.48% Unkown
HY-142689 Carboxylesterase-IN-3 Inhibitor 98.27% Unkown
HY-142688 Carboxylesterase-IN-2 Inhibitor 99.91% Unkown
HY-149818 8BTC Inhibitor / Unkown
HY-182632 LP-935001 / Unkown
HY-RS09454 NOTUM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W171983 Notum-IN-1 Inhibitor / Unkown
HY-148360 Notum pectinacetylesterase-1 Inhibitor / Unkown
HY-182402 Notum-IN-2 / Unkown
HY-RS21001 Notum Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27518 Notum Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NOTUM VGNC VGNC:104636
Bos taurus NOTUM VGNC VGNC:106845
Mus musculus NOTUM MGD MGI:1924833
Felis catus NOTUM VGNC VGNC:63863
Canis familiaris NOTUM VGNC VGNC:43901
Rattus norvegicus NOTUM RGD RGD:1307119
Others NOTUM NCBI