Apex2 - apurinic/apyrimidinic endonuclease 2 Gene

Also Known as ape2; C430040P13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77622

Summary

Predicted to enable DNA-(apurinic or apyrimidinic site) Endonuclease activity; double-stranded DNA 3'-5' exodeoxyribonuclease activity; and phosphoric diester hydrolase activity. Predicted to be involved in base-excision repair. Predicted to act upstream of or within DNA recombination and DNA repair. Located in mitochondrial inner membrane and nucleus. Orthologous to human APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2). [provided by Alliance of Genome Resources, Apr 2022]

Apex2 Products (1)

mRNA Protein Name
NM_029943.3 NP_084219.1 DNA-(apurinic or apyrimidinic site) endonuclease 2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
12573260 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12573260 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-(apurinic or apyrimidinic site) endonuclease 2

  • AP endonuclease 2

  • APEX nuclease 2

  • DNA-(apurinic or apyrimidinic site) lyase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131442 Alkyne-phenol 99.72% Unkown
HY-139912 Biotin-aniline 99.63% Unkown
HY-W614753 Biotin-naphthylamine 98.12% Unkown
HY-155639 Tyramide alkyne 99.50% Unkown
HY-173176 4-(2-Azidoethyl)phenol 99.89% Unkown
HY-RS00816 APEX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18986 Apex2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25475 Apex2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apex2 NCBI NCBI:27301