SCG2 - secretogranin II Gene

Also Known as SN; CHGC; EM66; SgII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7857

About SCG2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:223,596,940-223,602,361 (from NCBI)

This gene has 3 transcripts (splice variants) and 254 orthologues. Biased expression in adrenal (RPKM 212.1), brain (RPKM 97.1) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide Hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]

SCG2 Products (1)

mRNA	Protein	Name
NM_003469.5	NP_003460.2	secretogranin-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chemoattractant activity	IDA IDA: Inferred from direct assay	9473216	GOA
enables cytokine activity	IDA IDA: Inferred from direct assay	14970115	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in MAPK cascade	IDA IDA: Inferred from direct assay	14970115	GOA
involved in angiogenesis	IDA IDA: Inferred from direct assay	14970115	GOA
involved in eosinophil chemotaxis	IDA IDA: Inferred from direct assay	9473216	GOA
involved in induction of positive chemotaxis	IDA IDA: Inferred from direct assay	9473216	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	9473216	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	14970115	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14970115	GOA
involved in positive chemotaxis	IDA IDA: Inferred from direct assay	9473216	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	14970115	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	9473216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCG2 Protein Structure

Granin

0
100
200
300
400
500
617 a.a.

Protein Preferred Names	Protein Names
secretogranin-2	chromogranin-C

SCG2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SCG2	P13521	UBQLN1	Homo sapiens	Q9UMX0	Y2H	21516116
Intra	SCG2	P13521	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	SCG2	P13521	ATRIP	Homo sapiens	Q8WXE1	Y2H Prey Pooling	25416956
Intra	SCG2	P13521	ATRIP	Homo sapiens	Q8WXE1	Validated Y2H	25416956
Intra	SCG2	P13521	ATRIP	Homo sapiens	Q8WXE1	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCG2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70134	Secretogranin-2 Protein, Human (HEK293, His)	P13521 (S29-M617)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Intracranial Primitive Neuroectodermal Tumor	Intracranial Pnet Intracranial Primitive Neuroectodermal Neoplasm
Insulinoma	Islet Cell Adenoma Insulin-Producing Tumor Of Islet Cells Adenoma Islet Cell Islet Cell Tumor Experimental Organism Islet Cell Adenoma Neoplasm
Ganglioneuroma
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Collagenous Colitis	Colitis, Collagenous Microscopic Colitis, Collagenous Type
Malignant Pheochromocytoma	Pheochromocytoma, Malignant
Adrenal Medulla Cancer	Adrenal Medulla Neoplasm Adrenal Medulla Tumor Malignant Neoplasm Of Adrenal Medulla Malignant Tumor Of The Adrenal Medulla Adrenal Medulla Carcinoma Neoplasm Of Adrenal Medulla
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08333	MEN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12501	SCG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19380	Scg2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25872	Scg2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SCG2	VGNC	VGNC:64908
Mus musculus	SCG2	MGD	MGI:103033
Canis familiaris	SCG2	VGNC	VGNC:45905
Rattus norvegicus	SCG2	RGD	RGD:3626
Bos taurus	SCG2	VGNC	VGNC:34332
Macaca mulatta	SCG2	VGNC	VGNC:76977
Others	SCG2	NCBI