SCG2 - secretogranin II Gene

Homo sapiens

Also known as SN; CHGC; EM66; SgII

Gene ID: 7857 | Gene type: protein coding

About SCG2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:223,596,940-223,602,361 (from NCBI)

This gene has 3 transcripts (splice variants) and 254 orthologues. Biased expression in adrenal (RPKM 212.1), brain (RPKM 97.1) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide Hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]

SCG2 Products(1)

mRNA	Protein	Name
NM_003469.5	NP_003460.2	secretogranin-2 precursor

SCG2 Protein Structure

Granin

0
100
200
300
400
500
617 a.a.

Protein Preferred Names

Protein Names

secretogranin-2

chromogranin-C

Recombinant SCG2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70134	Secretogranin-2 Protein, Human (HEK293, His)	P13521 (S29-M617)	≥95%

Related Diseases

Diseases

Alias

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Intracranial Primitive Neuroectodermal Tumor

Intracranial Pnet

Intracranial Primitive Neuroectodermal Neoplasm

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Ganglioneuroma

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Collagenous Colitis

Colitis, Collagenous

Microscopic Colitis, Collagenous Type

Malignant Pheochromocytoma

Pheochromocytoma, Malignant

Adrenal Medulla Cancer

Adrenal Medulla Neoplasm	Adrenal Medulla Tumor
Malignant Neoplasm Of Adrenal Medulla	Malignant Tumor Of The Adrenal Medulla
Adrenal Medulla Carcinoma	Neoplasm Of Adrenal Medulla

Neuroendocrine Tumor

Neuroendocrine Neoplasm	Neuroendocrine Tumors
Carcinoma, Neuroendocrine

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12501	SCG2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SCG2	VGNC	VGNC:64908
Mus musculus	SCG2	MGD	MGI:103033
Canis familiaris	SCG2	VGNC	VGNC:45905
Rattus norvegicus	SCG2	RGD	RGD:3626
Bos taurus	SCG2	VGNC	VGNC:34332
Macaca mulatta	SCG2	VGNC	VGNC:76977
Others	SCG2	NCBI