Rictor - RPTOR independent companion of MTOR, complex 2 Gene

Also Known as AVO3; 4921505C17Rik; 6030405M08Rik; D530039E11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 78757

Summary

Enables ribosome binding activity. Involved in embryo development; regulation of protein kinase B signaling; and regulation of protein phosphorylation. Acts upstream of or within several processes, including positive regulation of actin filament polymerization; regulation of GTPase activity; and regulation of protein phosphorylation. Part of TORC2 complex. Is expressed in early conceptus and oocyte. Orthologous to human RICTOR (RPTOR independent companion of mTOR complex 2). [provided by Alliance of Genome Resources, Apr 2022]

Rictor Products (1)

mRNA Protein Name
NM_030168.3 NP_084444.3 rapamycin-insensitive companion of mTOR

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18566586 MGI
enables ribosome binding IDA
IDA: Inferred from direct assay
21045808 MGI
Biological Process GO Annotation Evidence References Source
involved in embryo development ending in birth or egg hatching IMP
IMP: Inferred from mutant phenotype
16962829 MGI
acts upstream of or within positive regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
15467718 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
15467718 MGI
acts upstream of or within regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
15467718 MGI
acts upstream of or within regulation of establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
24740015 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24740015 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
24740015 MGI
acts upstream of or within regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
24740015 MGI
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
16962829 MGI
involved in regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
23092880 MGI
Cellular Component GO Annotation Evidence References Source
part of TORC2 complex IDA
IDA: Inferred from direct assay
16962653 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rapamycin-insensitive companion of mTOR

  • AVO3 homolog

  • mAVO3

  • protein pianissimo

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-19307 SB-273005 99.94% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122022 JR-AB2-011 Inhibitor 98.15% Unkown
HY-RS11969 RICTOR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17350 Rictor Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23804 Rictor Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rictor NCBI NCBI:253260