Apaf1 - apoptotic peptidase activating factor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78963

Summary

Enables heat shock protein binding activity and identical protein binding activity. Involved in several processes, including animal organ development; cardiac muscle cell apoptotic process; and cellular response to transforming growth factor beta stimulus. Located in cytoplasm. Part of apoptosome. Used to study visual epilepsy. Biomarker of brain ischemia; colon cancer; middle cerebral artery infarction; and muscular atrophy. Orthologous to human APAF1 (apoptotic peptidase activating factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Apaf1 Products (1)

mRNA Protein Name
NM_023979.2 NP_076469.1 apoptotic protease-activating factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
22143029 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
17483091 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16979168 RGD
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
18197610 RGD
involved in cell differentiation IEP
IEP: Inferred from expression pattern
15504912 RGD
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
11003619 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
27665619 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
18325779 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
14973070 RGD
Cellular Component GO Annotation Evidence References Source
part of apoptosome IDA
IDA: Inferred from direct assay
17483091 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apoptotic protease-activating factor 1

  • apaf-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-126741 Azadirachtin 99.06% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y0598 trans-Chalcone 99.25% Unkown
HY-18633 MDK83190 Activator 98.61% Unkown
HY-125018 QM31 Inhibitor 95.00% Unkown
HY-103349 PETCM 99.68% Unkown
HY-119979 Cardanol monoene Inducer 99.51% Unkown
HY-116692 Apoptosis inducer 34 99.9% Unkown
HY-136893 SP-6-27 / Unkown
HY-RS00801 APAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-171447 LPT99 Inhibitor / Unkown
HY-RS17757 Apaf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24224 Apaf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apaf1 NCBI NCBI:317